Hey, all welcome back to the real-life pharmacology podcast. I'm your host, pharmacist Eric Christensen.

And today on this podcast, I'm going to be covering the combination of budesinide and formoderal.

Now, the brand name of this medication is Symbicourt, and of course, I am talking about the inhaled dosage form.

I do have another podcast on Budesinide specifically, which is the oral formulation used in

Crohn's and ulcerative colitis, so you can check that out.

On this episode specifically, I'm going to focus on the inhalation form of the drug combination here.

So mechanistically, for Motorola is a long-acting beta agonist, and how this drug works in the combination

is it activates beta to receptors in the lungs,

and this causes a smooth muscle relaxation in the lungs, bronchials,

and allows the opening up of that airway, and hence allows a patient to breathe a little bit easier.

Now, Budesinide is a corticosteroid.

I've kind of covered that in that other podcast as far as mechanism of action goes.

But ultimately, in asthma, particularly, there is a large component of inflammation in that airway.

And that can sometimes happen in COPD as well.

But inhaled corticosteroids are one of the mainstays in chronic maintenance treatment in asthma therapy.

And they are good because they reduce that inflammation.

That's how the steroids work there.

Now, the one of the big reasons I wanted to cover this medication

is we have had some recent guideline changes in the last year or so here,

year or two, and particularly in the last year or so here, here too, and particularly in

the setting of asthma. So we have new recommendations saying that it is okay to use

budescineid and formalerole combination uh, one inhalation as needed up to, uh,

...