Bromocriptine Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 11 February 2021

⏱️ 11 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this episode, I discuss bromocriptine pharmacology. It is a dopamine agonist that can be used for hyperprolactinemia and Parkinson's symptoms.

One of the major side effects of bromocriptine is nausea which stems from its dopamine agonist action.

Because bromocriptine is a dopamine agonist, it can counteract the action of antipsychotics.

Bromocriptine is broken down by CYP3A4, so drug interactions can be common. Erythromycin, some of the azole antifungals, verapamil, grapefruit juice, and diltiazem are all medications that can increase concentrations.

Transcript

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0:00.0	Hey, all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.
0:06.6	Definitely go check out RealLife Pharmacology.com.
0:10.9	Snag your free 31 page PDF on the top 200 drugs.
0:15.5	If you work in healthcare, if you're in pharmacy school, med school, nursing school, that resource is definitely
0:24.0	going to be a great refresher for you at a minimum, but I think a lot of you will pick up a few
0:30.5	things from it as well. Again, free 31-page PDF of the top 200 drugs and kind of I break them down by the really the most important
0:40.4	things you need to know so go check that out again real life pharmacology.com all right so let's get
0:47.9	into the drug of the day today and I will say I do accept requests from from time to time as many as I can get to.
0:57.6	So you can probably reach out to me at LinkedIn, Eric Christensen, FarmD, BcGP, Bcps,
1:03.8	or Med Education 101 at gmail.com.
1:08.8	If you have any comments or questions, I do my best to get to ones.
1:15.6	So anyway, with that, bromocryptine is the drug of the day today. And there's a couple of brand names
1:23.4	with this medication. Medication parlodal is one, and a cyclocet is the other.
1:30.3	Now, interestingly, cyclocet is used in diabetes, and Parlotal, which is kind of the older brand name,
1:39.6	I would say that's the one I've heard most in clinical practice.
1:44.9	That one is historically used for things like hyperprolactinemia,
1:52.0	potentially like Parkinson's type symptoms.
1:56.5	But it is pretty rare that you see this medication,
2:01.0	and maybe you've never seen it.
2:02.7	I know personally I've seen it a handful of times.
2:07.7	Probably the most common situation is hyperprolactinemia that I have seen it.
2:13.5	And this medication works as a dopamine agonist.
	...

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