Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

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All right.

So the drug of the day is Baclophon.

Brand name of this medication is Leorazol.

I can't say I see that brand name used terribly often, but I have seen it come across

it a couple of times.

This medication is used primarily for muscle spasms and spasticity associated with various muscle disorders.

Off-label uses, there are some reported off-label uses such as Elko-Eustis order, hiccups as well.

Me personally, I have not seen Baclophen used in those off-label settings, but I did want to mention them at least.

By far, in clinical practice, I see the medication used for spasms or spasticity.

Mechanistically, this actually works by blocking reflexes at the spinal cord level,

so kind of in that central nervous system area.

And it's likely due to hyper-polarization of neuronal cells or neuronal endings,

and that ultimately leads to a relaxation of muscles, which obviously

helps spasms and spasticity in general.

All right, so when I think of baclophon, one of the things that I hear a lot or that I've seen patients be on quite a bit is baclophon pumps.

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