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Nature Podcast

Briefing Chat: What Brazilian centenarians could reveal about the science of ageing

Nature Podcast

podcast@nature.com

Science, Technology, News

4.5893 Ratings

🗓️ 30 January 2026

⏱️ 10 minutes

🧾️ Download transcript

Summary

In this episode:



00:36 Study probes genetics of extreme longevity

Nature: Still working at 107: supercentenarian study probes genetics of extreme longevity



05:32 Controlling fluorescent proteins’ brightness with magnets

Nature: ‘Remote controlled’ proteins illuminate living cells


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Transcript

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0:00.0

Hi listeners, Benjamin here.

0:05.4

Welcome to the Nature Briefing podcast, the Friday show where we talk about a couple of stories we have read in the Nature briefing,

0:12.3

which is, of course, nature's daily roundup of the latest science stories.

0:16.2

We're actually recording this in the office today, so you might hear a few folk walk past.

0:20.4

But one of the folk who hasn't walked past and is here to talk science with me is nick petrich chow nick how you doing today i'm doing well ben i have indeed stopped to come and tell you about some interesting science that i think you'll agree shines a light on some new research well that has baited the hook i shall say but i've got a story that i'm going to talk about first. And it's something that I read about in nature. And it's about the preliminary findings from a study in Brazil, investigating why some people live to a very big age, like over a hundred. So this is looking at things that I'm guessing allowed them to get to such a great age.

0:54.6

Yeah, and it's something that we've covered on the show before, right?

0:57.6

The science of ageing is incredibly complex, but of course it's a huge interest to a lot of researchers as well.

1:05.2

Not just extending lifespan, but extending healthy lifespan as well.

1:10.2

And this story in particular looks at the DNA

1:12.5

Longuevo study, which is Portuguese for long-lived DNA. And this study is still recruiting

1:18.8

participants. But scientists have already sequenced the genomes of more than 160 centenarians,

1:25.2

so folk over 100, and 20 participants are super centenarians. Those are people who've reached over 110 years old.

1:33.6

Wow, okay, so such incredible lifespans, and hopefully their genetics can tell us something about how they got there.

1:39.4

And genetics is the important word as well. So yeah, you're right. It's hope that understanding why folk like

1:44.5

this can live so long is something that scientists are interested in investigating, you know,

1:50.7

for clues about human longevity. And as I say, genetics is key. Because when you see a local news

1:55.9

show and they've spoken to someone who's over 100 and you ask them about their lifestyle,

1:59.8

they say, well, I smoke 20 cigarettes a day and I have a bottle of gin for breakfast, right?

2:03.3

So we need to be a little bit careful taking them in isolation.

2:06.3

And that appears to be relevant here as well.

2:08.6

So early data showed that the supercentenarians in this study did not have especially

2:14.1

healthy diets or exercise ratios or access to high-end medicine for most of their lives.

...

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