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Nature Podcast

Briefing chat: ‘Can it run Doom?’ — why scientists got brain cells and a satellite to play the classic game

Nature Podcast

podcast@nature.com

News, Science, Technology

4.5893 Ratings

🗓️ 13 March 2026

⏱️ 11 minutes

🧾️ Download transcript

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0:00.0

Hi listeners, Benjamin here. Welcome to The Nature Briefing podcast, the Friday show where we talk about a few things we've read about in the nature briefing.

0:13.0

We've got one quick story today, and we're back in the world of video games.

0:18.3

Now, specifically, a historically important entry to the medium, and that is

0:23.8

Doom, released in 1993 by ID Software. It's a first-person shooter that will be familiar to many

0:31.4

of you listening right now. Perhaps like me, even if you've not played it in many years,

0:36.1

the cheat code IDKFA is seared into your brain.

0:41.2

But this isn't a trip down memory lane today. Doom has become something of a workhorse of science.

0:48.6

And writing about this is Nature's Rachel Fieldhouse, who joins me down the line from Australia.

0:53.5

Rachel, thank you so much

0:54.5

for being here today. Thanks for having me. And I say there it's a workhorse. It's been used as a tool

0:58.8

across many scientific disciplines, right? Absolutely. Everything from computer science and AI all the way to

1:05.8

biology. And there's a particular subculture that I have been fascinated about for years, which I think perhaps is the main thrust of your article. And this is this can it play doom, almost meme, I guess. Now, basically if something has a screen, people will try and get it to run doom.

1:23.1

Essentially, yeah. We've seen everything from calculators and smart fridges to even computerized pregnancy tests and the little digital bars on the top of MacBook keyboards.

1:33.5

It's glorious, right? I mean, you and I have been showing them. I think electric toothbrush is one of my favorites.

1:37.5

Getting Doom to play inside of Doom is a recursive nightmare. We haven't got time to talk about. But there are hundreds of them, and listeners can go and find

1:44.6

them on the internet, and many of them are glaringly silly. But there's a new one that's been

1:49.9

added to the list that you've really been taking a look at. Yes, so a team in Australia have

1:55.3

decided to essentially get their biological computer to run Doom. So their computer is basically a collection of about 200,000 neurons on top of a silicon

2:04.9

chip.

2:05.9

And so what they've done is they worked with this independent researcher from Singapore, who

2:11.6

wrote the code, and it was part of a hackathon that they ran.

2:16.0

And the whole point of the challenge was, can people get Doom to run on their biological computer?

...

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