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Nature Podcast

Botanical mystery solved: how plants make a crucial malaria drug

Nature Podcast

podcast@nature.com

News, Science, Technology

4.5893 Ratings

🗓️ 18 March 2026

⏱️ 16 minutes

🧾️ Download transcript

Summary

In this episode:


00:46 Piecing together a biochemical puzzle

Research Article : Lombe et al.


12:26 Research Highlights

Nature: Electric-vehicle batteries toughen up to beat the heat

Nature: Live parrots were carried across the Andes before the Incas’ rise


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Transcript

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0:00.0

Nature.

0:02.0

In a experiment.

0:05.0

Why is blight so far?

0:08.0

Like, it sounds so simple.

0:09.0

They had no idea.

0:11.0

But now the data's...

0:12.0

I find this not only refreshing, but at some level astounding.

0:19.0

Nature.

0:20.0

Nature.

0:25.4

Welcome back to the nature podcast.

0:30.0

This week, I'm picking some puzzling plant biochemistry.

0:31.9

I'm Benjamin Thompson. I'm Benjamin Thompson.

0:50.7

Okay. Plants of the Sinchona genus are fairly unassuming things.

0:57.8

Native to South America, they're sometimes described as large shrubs and sometimes as small trees. But some species make some incredibly useful chemicals. For reasons that aren't entirely understood,

1:06.0

these plants produce a diverse bunch of nitrogen-containing compounds, collectively known as cinchona

1:13.6

alkaloids. The most well-known of these is quinine. Perhaps you know it as quinine, the earliest known

1:20.6

naturally occurring malaria treatment. But there are others too, including molecules that play

1:26.6

important roles as catalysts for chemical reactions.

1:30.8

And although these alkaloids can be made in the lab,

1:34.1

cinchona plants, also called Chinchona plants, remain the biggest source of the molecules.

1:40.3

But there's a catch. Nobody quite knows how the plants make them. Figuring out the biochemistry

1:46.4

underpainting their production is of great interest to researchers, as it might allow them to adapt

...

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