Botanical mystery solved: how plants make a crucial malaria drug
Nature Podcast
podcast@nature.com
4.5 • 893 Ratings
🗓️ 18 March 2026
⏱️ 16 minutes
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Summary
In this episode:
00:46 Piecing together a biochemical puzzle
Research Article : Lombe et al.
12:26 Research Highlights
Nature: Electric-vehicle batteries toughen up to beat the heat
Nature: Live parrots were carried across the Andes before the Incas’ rise
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Transcript
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| 0:00.0 | Nature. |
| 0:02.0 | In a experiment. |
| 0:05.0 | Why is blight so far? |
| 0:08.0 | Like, it sounds so simple. |
| 0:09.0 | They had no idea. |
| 0:11.0 | But now the data's... |
| 0:12.0 | I find this not only refreshing, but at some level astounding. |
| 0:19.0 | Nature. |
| 0:20.0 | Nature. |
| 0:25.4 | Welcome back to the nature podcast. |
| 0:30.0 | This week, I'm picking some puzzling plant biochemistry. |
| 0:31.9 | I'm Benjamin Thompson. I'm Benjamin Thompson. |
| 0:50.7 | Okay. Plants of the Sinchona genus are fairly unassuming things. |
| 0:57.8 | Native to South America, they're sometimes described as large shrubs and sometimes as small trees. But some species make some incredibly useful chemicals. For reasons that aren't entirely understood, |
| 1:06.0 | these plants produce a diverse bunch of nitrogen-containing compounds, collectively known as cinchona |
| 1:13.6 | alkaloids. The most well-known of these is quinine. Perhaps you know it as quinine, the earliest known |
| 1:20.6 | naturally occurring malaria treatment. But there are others too, including molecules that play |
| 1:26.6 | important roles as catalysts for chemical reactions. |
| 1:30.8 | And although these alkaloids can be made in the lab, |
| 1:34.1 | cinchona plants, also called Chinchona plants, remain the biggest source of the molecules. |
| 1:40.3 | But there's a catch. Nobody quite knows how the plants make them. Figuring out the biochemistry |
| 1:46.4 | underpainting their production is of great interest to researchers, as it might allow them to adapt |
... |
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