Breakthrough Blood Test Achieves 96% Accuracy for Chronic Fatigue Syndrome

Dr. Joseph Mercola - Take Control of Your Health

Briana Mercola

Health & Fitness, Health, Alternative Health

4.6 • 1.5K Ratings

🗓️ 20 November 2025

⏱️ 8 minutes

🔗️ Recording | iTunes | RSS

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Summary

A groundbreaking blood test identified myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with up to 96% accuracy, using 3D genomic mapping to detect immune and metabolic disruptions in blood cells
ME/CFS, a chronic, multisystem illness that can devastate daily life, affects an estimated 17 to 24 million people worldwide
Research points to the gut-brain-immune axis as a key driver, linking post-infectious inflammation, leaky gut, and microbial imbalance
Excess serotonin activity, often triggered by SSRIs, may worsen fatigue by slowing cellular energy production and increasing inflammation
True recovery means restoring balance: calming the nervous system, repairing the gut, cutting inflammatory seed oils from the diet, and rebuilding cellular energy so the body can heal itself

Transcript

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0:00.0	What if a simple blood test could finally tell you whether your crushing exhaustion has a biological cause, and do it with remarkable accuracy?
0:08.0	Welcome to Dr. Mercola's cellular wisdom. Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go.
0:17.0	No reading required. Subscribe for free at Mercola.com for the latest health insights.
0:21.7	Hello and welcome to Dr. Mercola's cellular wisdom. I'm Ethan Foster. Today we're unpacking
0:28.2	new research that use 3D genomic mapping to identify myalgic encephalomyelitis, also called
0:35.2	Chronic Fatigue Syndrome, with striking precision and what that means for you
0:39.6	if fatigue has taken over your life. I'm Alaris Guy. We're going to translate the findings into
0:45.2	clear takeaways. How this test works, why immune and metabolic dysfunction are central,
0:50.6	and which practical steps drawn from the research can help you restore balance without
0:55.7	guessing.
0:56.7	An estimated 17 to 24 million people worldwide live with M.E. slash CFS. Yet for decades,
1:05.0	there hasn't been an objective test. Many of you have normal labs, but can't get through
1:09.7	a day without crashing. The study we're
1:11.9	discussing measured three Dai Jian folding patterns in immune cells and reached up to 96% overall
1:18.3	accuracy, with 92% sensitivity and 98% specificity. That level of performance can shorten years
1:26.4	of uncertainty. The method, called Episwitch 3D genomics,
1:30.3	examines how your DNA folds inside immune cells.
1:34.3	Those folds act like switches that turn genes on or off.
1:38.3	Researchers scanned over a million folding points
1:41.3	and focused on a defined set linked to
1:44.2	immune and inflammation pathways. In ME slash CFS, these switches form a distinct fingerprint
1:52.0	that separates affected individuals from healthy controls.
	...

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