Have you ever wondered if there are more natural ways to lower your high blood pressure,

guard against Alzheimer's, loose weight, feel better? Well, it turns out there is. Welcome to the

Nutrition Facts podcast. I'm your host, Dr. Michael Greger. Today, we look at boosting our GLP1,

the way Mother Nature intended.

Plant predominant diets may play a major role in reversing the obesity and chronic disease epidemics, just as plant-based dietary interventions may arrest revert, type 2 diabetes

and cardiovascular disease on an individual basis.

In a previous video, I showed how a tofu burger boosted levels of the appetite-suppressing

hormone gLP 1 higher than a meat burger in both people with diabetes and without,

even though the two burgers were matched for calories and macronutrients.

One thing may have given the plant-based meal on edge, though, at least over time, increased

fiber.

The bacterial fermentation of dietary fibers in the colon produces short-chain fatty acids

called acetate, propionate, and butyrate, which in turn stimulate release of GOP-1.

In this way, prebiotics like dietary fiber represent an alternative strategy for boosting production of GOP1. In this way, prebiotics like dietary fiber represent an alternative

strategy for boosting production of GOP1. In contrast, a bacterial breakdown product of

triptophan, which is concentrated in animal protein, has been found to have opposite effects on

GOP1 release. How do we know fiber-derived short-chain fatty acids boosts GLP1 in the first place?

Well, all three circulating short-chain fatty acids were associated with higher

GLP-1 concentrations in the blood, but that doesn't prove cause and effect.

For that, you need to stick tubes in people's butts.

Getting a rectal infusion of acetate indeed causes GOP-1 levels to go up.

And the amount of acetate concentrations in the blood reached after rectal infusion were

...