Biology of aging and tips to slow it down | Matt Kaeberlein, PhD

The Proof with Simon Hill

Simon Hill

Nutrition, Education, Self-improvement, Health & Fitness

4.9 • 3.1K Ratings

🗓️ 27 February 2023

⏱️ 179 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more. Specifically, we discuss: Intro (00:00) Aging and disease (03:42) Evolutionary conserved processes and human life span (17:41) Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29) Aging process and the burden of senescence cells (34:06) Keys to a longer, healthier life (45:08) Sleep and exercise (55:38) Calorie restriction, longevity, and prolonged fasting (1:15:23) Protein restriction and its implications (1:32:14) Plant protein vs animal protein (1:43:31) Natural occurring polyphenols and supplements related to longevity (1:53:06) Rapamycin and rapamycin derivatives (2:13:53) Anti-aging compounds (2:29:38) Ethical implications of prolonging the life (2:51:08) Outro (2:57:23) To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here. Discover more insights and supporting resources in the full show notes. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary two-week meal plan and high protein Plant Performance recipe book

Transcript

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0:00.0	Hey there, I've got a very quick message to share with you before we jump into the episode.
0:08.1	Let's keep this under 30 seconds, shall we?
0:11.5	This episode is proudly brought to you by Amille.
0:13.7	Amille is a plant-based wellness company focused on formulating evidence-based supplements
0:18.2	to optimize our health.
0:19.8	I personally take Amille's essential aid multi-nutrient to how I start my day, which contains
0:25.0	eight essential nutrients in the right forms and dosages to perfectly complement a plant-rich
0:30.1	diet.
0:31.1	Amille offers no magic pills or hyperbolic claims, just good quality supplements that
0:36.3	we can trust.
0:37.3	To check out Amille and get 10% off your first order, visit theproof.com forward slash
0:42.5	friends.
0:43.5	I'll pop a link to that in the show notes.
0:49.1	Probably the most important thing is just to appreciate that there really is this biology
0:53.1	of aging.
0:54.1	That there are biological processes that determine the rate at which different animals
0:58.8	age and within the same species, within humans, the rate at which individual people age.
1:05.8	So there is this biological process that we can study and understand very much like development
1:12.9	as a process.
1:14.1	And in principle, when we understand it well enough, we can modify that biology in a way
1:20.0	that will delay the functional declines and diseases that go along with aging.
1:24.2	And in fact, we as a field now have been extremely successful at doing this in laboratory
	...

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