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Science Quickly

Better Gut Microbiome Census through Computing

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 18 January 2016

⏱️ 3 minutes

🧾️ Download transcript

Summary

Sophisticated computational techniques make it possible to analyze gene samples from all the bacteria in the gut at once to take a census of the species present.   Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years. Yacold also

0:11.5

partners with nature portfolio to advance gut microbiome science through the global grants for

0:16.6

gut health, an investigator-led research program. To learn more about Yachtold, visit yawcult.co.

0:22.6

That's Y-A-K-U-L-T-C-O-J-P. When it comes to a guide for your gut, count on Yacult.

0:34.0

This is Scientific American 60-second science. I'm Cynthia Graber. Got a minute? In recent years,

0:40.8

scientists have shown that the microbes that live in our guts play crucial roles in our lives.

0:45.2

They're involved in digestion, obesity, even mood. And a few can cause serious illness. So it would

0:50.9

be a good idea to know the identities of the bacteria inside us, and yet that info has been incomplete.

0:56.7

But now researchers have developed a technique to get a better census of the gut microbiome.

1:01.4

And using the new system, the researchers have found that our microorganisms are even more diverse than we knew.

1:06.8

The report is in the journal Nature Biotechnology.

1:09.5

Currently, researchers analyze microbial diversity by taking a sample they hope includes the

1:13.6

different kinds of bacteria in the gut.

1:15.6

They then try to identify the different species by looking at their genomes, but they can

1:20.2

only do that second hand by trying to piece together many short snippets of DNA, which can

1:25.1

be confusing and inadequate when dealing with numerous different

1:28.0

kinds of bacteria. So geneticists at Stanford University got together with computer scientists to

1:33.5

come up with a new approach. They used sophisticated computational techniques that enabled them to

1:38.4

analyze much longer stretches of DNA, which included many genes that would be missed with the older

1:43.2

system. For example,

1:44.6

when they tested the gut microbiome from a healthy human male the old way, they found

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