Autophagy Scientist Dr. Kurt Escobar: How to Upregulate Autophagy in Humans, Dispelling the Hype about Fasting, Mtor & More!

Optimal Protein Podcast with Vanessa Spina

Vanessa Spina

Fitness, Health & Fitness, Nutrition

4.5 • 758 Ratings

🗓️ 29 July 2024

⏱️ 98 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

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Hi friends! This episode is featuring autophagy scientist Dr. Kurt Escobar on how to upregulate autophagy in humans, dispelling the hype about fasting, Mtor & more! See full bio below.

*TIMESTAMPS BELOW

Studies mentioned in this episode:

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

Does Exercise Regulate Autophagy in Humans? ASystematic Review and Meta-Analysis

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*TIMESTAMPS

5:00 Kurt’s background and interest in studying in autophagy

9:13 what is autophagy?

10:30 why autophagy is important (avoiding disease and aging)

12:00 autophagy as cellular housekeeping

13:00 autophagy, exercise & redox potential

13:30 quantifying exercise vs fasting for autophagy

17:00 no current consensus on how much autophagy is required for humans and implications for longevity and aging

18:00 limitations to longevity research in humans

19:00 problems with extrapolating rodent data to humans

20:00 fasting in mice stimulating ampk/PGC1alpha and mitochondrial biogenesis VS humans according to newest research

21:00 what do exercise and caloric restriction have in common with up regulating autophagy

23:00 metabolic autophagy vs “housekeeping” autophagy

25:40 exercise upregulates the housekeeping autophagy

29:29 intermittent fasting and autophagy

44:30 meta analysis & systematic review on best exercises for autophagy

52:00 autophagy threshold and different types of exercise for autophagy

56:00 mTOR suppression on longevity, disregulated mTor vs “good” mTOR

1:10:00 what is V02 Max? Improving V02 Max for health and longevity

1:15:00 Heat Shock Proteins

1:19:00 cold exposure vs heat exposure for muscle repair and recovery

1:21:00 physiological stressors & benefits

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Dr. Kurt Escobar completed his PhD at the University of New Mexico. His research centers on how exercise and nutrition can improve human health, function, and performance. His work ranges from exercise metabolism, the effects of exercise and nutrition on metabolic health, and sports nutrition, to the cellular responses to exercise including autophagy. He teaches courses on the physiology of exercise, exercise programming and prescription in health and disease, and exercise nutrition. Check out his Youtube Channel HERE

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Transcript

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0:00.0	Welcome to the Optimal Protein Podcast. I'm Vanessa Spina.
0:05.4	Hello, my friends. Welcome back to the podcast. I am so excited for today's episode. We have
0:12.1	Dr. Kurt Escobar joining us today. And he is an expert on autophagy. He actually earned his
0:19.2	PhD studying autophagy. He is currently an associate professor
0:24.8	of exercise physiology and co-director of the physiology of exercise and sport lab at California
0:32.1	State University in Long Beach. And his research centers around how exercise and nutrition can improve human health,
0:39.8	function, and performance, ranging from exercise metabolism, the effects of exercise and
0:45.2	nutrition on metabolic health and sports nutrition, all the way to the cellular responses
0:50.7	to exercise, including autophagy. And today's episode episode we talk all about atopagy one of my
0:56.9	favorite topics and we talk about how autophagy is stimulated and exactly how it is stimulated from
1:04.8	certain protocols so we talk about caloric restriction intermittent fasting exercise and whether it is
1:10.8	actually stimulated by intermittent fasting, exercise, and whether it is actually stimulated by
1:12.2	intermittent fasting or not, what the research shows, and all of these different mechanisms
1:17.1	surrounding Emptor and AMPK, and really getting clear on what autophagy is, and when it is actually
1:26.1	upregulated, whether or not it is on or off or activated or basically
1:30.6	always on in the background. And we really go in depth on clarifying all of these concepts
1:36.5	around autophagy on today's episode. The central theme is talking about what the evidence and
1:42.5	scientific data really shows us in terms of what autophagy
1:47.0	can be upregulated from these different protocols, whether or not it can.
1:52.0	And these quote unquote biohacks and things that are out there on the internet,
1:56.0	what the scientific literature really shows in terms of autophagy and what it can do for us in terms of enhancing
2:02.8	longevity lifespan balancing the intake of protein and mTOR and the activation of ampk with fasting
	...

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