Anthropic’s Mythos is a cyber-weapon, so you can’t have it | E2273
This Week in Startups
Jason Calacanis
4.2 • 1.4K Ratings
🗓️ 9 April 2026
⏱️ 77 minutes
🧾️ Download transcript
Summary
Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction.
Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council.
Together, they’ll test how quickly and easily the model can thwart today’s most elite cybersecurity protocols, and try to develop fresh protocols to keep our most sensitive and critical software systems safe and intact. Once Mythos or a similarly powerful model hits the streets… it’s all over!
Plus, we’re checking out the real-time SaaSpocalypse monitor Death By Clawd, and chatting with its creator, Gyani, about how it feels to have your startup one-shotted by Anthropic’s latest model.
Guests
Rob May: https://x.com/robmay
Neurometric: https://www.neurometric.ai/
Neurometric SLM Marketplace: https://marketplace.neurometric.ai/
Death by Clawd: https://deathbyclawd.com/
Nick O’Neill: https://x.com/chooserich
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Today’s show:
Timestamps:
0:00 Anthropic's new, powerful 'Mythos' model
3:50 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!
5:26 Neurometric's Rob May joins the show
10:04 Sam Altman's talent exodus
10:50 Render - Go to https://render.com/twist to apply for the Render Startup Program. You'll get anywhere from $500 to $100,000 in free credits.
11:50 Has Anthropic Passed OpenAI?
15:44 When will Claude release Mythos? Polymarket: https://polymarket.com/event/claude-mythos-released-by
18:32 The AI race turns existential
19:16 Would Anthropic's model give the CIA the ability to hack a foreign government?
20:04 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.
21:19 Should AI be nationalized?
29:43 Subsidizing secret AI development.
30:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist
31:29 How much of the military's $1.5T will go to AI cybersecurity?
35:17 Nick O'Neill's "not sponsored" call-in.
38:24 What is an SLM?
42:01 Tactical/Practical: How can you tune SLMs
45:43 How Neurometric can afford 100M free tokens per month for its users?
49:04 What is "harness engineering"?
50:58 Tactical/ Practical: Every Reddit rant is a startup idea
1:00:25 Why Meta is the most un-innovative AI company in the world.
1:03:43 Gyani of Deathbclawd joins the show — Is your company COOKED?
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | All right, everybody, welcome to Twist. It's April 8th, 2026. My co-host Alex is with me. We've got a bunch of guests today, and we've got a major breaking news story, which is that Anthropic released a promo video and a thread that their new model, Alex, is so powerful that they cannot release it. |
| 0:23.1 | We knew this day would come. |
| 0:24.9 | The day is here. |
| 0:26.1 | Why can't they release it? |
| 0:27.9 | They believe when they tested it, or they found out when they tested it, that it would |
| 0:33.3 | try to escape. |
| 0:35.4 | That was one issue, but a bigger issue was it could find exploits in 10, 20, 30-year-old |
| 0:40.8 | software projects that, and it could thread together multiple security vulnerabilities. |
| 0:46.8 | Catch everybody up in the audience on this incredibly important story. |
| 0:52.2 | This weekend startups is brought to you by LinkedIn Jobs. Hire right the first time. Post your job |
| 0:58.1 | and get $100 off towards your job post at LinkedIn.com slash twist. Grasshopper Bank. Time is money. |
| 1:05.3 | Don't waste either. Go to grasshopper.com slash twist and get an exclusive $500 cash bonus just for opening an account. |
| 1:13.6 | And Render. Find out why 5 million developers are already using the all-in-one cloud platform |
| 1:19.2 | render. Go to render.com slash twist and apply for the Render startup program to get |
| 1:24.3 | $500 to $100,000 in free credits depending on your stage and backers. |
| 1:32.3 | Big model race going on between the major AI labs. |
| 1:35.3 | Anthropic is now very far out in front with its new model called Mythos. |
| 1:39.3 | It is a general purpose LLM, so it's not tuned for one specific task. |
| 1:43.3 | It is currently in preview. You cannot use it. |
| 1:46.0 | A consortium of companies, Jason, are working with Anthropic to basically use it in a defensive |
| 1:51.1 | capacity because, as you said, mythos is incredible at both finding, exploiting, and patching |
| 1:57.2 | security vulnerabilities in software that humans have often missed. |
... |
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