3 AI Agents That Actually Replaced Human Jobs | E2272
This Week in Startups
Jason Calacanis
4.2 • 1.4K Ratings
🗓️ 7 April 2026
⏱️ 79 minutes
🧾️ Download transcript
Summary
Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era.
And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal!
Hosts
Jason Calacanis: http://x.com/jason
Lon Harris: https://x.com/lons
Guests
Ryan Carson: https://x.com/ryancarson
Clawchief: https://github.com/snarktank/clawchief
Alex Finn: https://x.com/AlexFinn
Creator Buddy: https://www.creatorbuddy.io/
Yazin Alirhayim: https://x.com/yazins
OpenOats / Sidecast: https://github.com/yazinsai/OpenOats
Further Reading
The Checklist Manifesto by Atul Gawande: https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000
Marc Andreessen on AI job loss: https://x.com/pmarca/status/2040919227641856307
OpenAI acquires TBPN: https://openai.com/index/openai-acquires-tbpn/
This Week In Startups is made possible by:
Gusto - https://Gusto.com/twist
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Plaud - https://Plaud.ai/twist
Today’s show:
Timestamps:
0:00 Welcome back to TWiST
0:32 Jason's thinks Andor is as good as Empire Strikes Back…
2:30 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!
3:26 Check out the checklist manifesto! https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000
6:36 Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show
10:28 Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at https://Gusto.com/twist.
10:46 People are automating their coworkers and getting them fired…
18:32 Anthropic Bans OpenClaw
20:06 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist
24:06 How "caveman talk" makes AI works better
27:31 Alex thinks $2000/ month subscription plans are inevitable for AI.
29:31 Why is nobody using the leaked Anthropic Model?
30:30 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist
32:37 Open models have been 6 months behind for the past few years
35:53 Why did OpenAI acquire TBPN?
42:01 Tactical/ Practical: The product itself is the most important thing
44:31 Demo or Die! Yazin is back to show off OpenOats
55:05 Ryan's "Claw Chief" https://github.com/snarktank/clawchief/blob/main/skills/executive-assistant/SKILL.md?plain=1
1:02:14 Alex's big announcement, "Henry intelligent machines"
1:12:33 Alex Finn DESTROYS Higgsfield's marketing strategy
1:15:35 Throwback to "Pay Per Post"
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | All right, everybody, welcome back to Twist. |
| 0:01.4 | It is April 6th, 2025. |
| 0:03.9 | How do I know it's April 6th? |
| 0:05.3 | Mall is out today. |
| 0:06.6 | Oh, right. |
| 0:07.3 | The new Star Wars animated and it's got great reviews. |
| 0:10.8 | I love watching Clone War, Star Wars, Rebels. |
| 0:14.0 | I'm excited to check it out. |
| 0:15.1 | I'll tell you what I don't like, though. |
| 0:17.5 | We're already in the point where any new Star Wars thing comes out and immediately people start comparing it to Andor. That's what is like, oh, this is the andor of cartoons. And it's like I'm already tired of that. It doesn't have to be Andor to be good. Let's just enjoy it for what it is. No, I'm going to take the other side. I'll tell you why I'm'm going to take the other side. Andor set the high water mark. |
| 0:38.1 | So it used to be like, is this as good as Empire Shricks back? Yes. And so, you know, now I consider Andor an empire. This is going to be big for people. Whoa, this is about to be controversial. I consider them equal. Wow. I consider them equal. Now, that doesn't mean I don't have an affinity for empire as a kid. |
| 0:56.8 | It was like the most meaningful. equal. Wow. I consider them equal. Now, that doesn't mean I don't have an affinity for empire |
| 0:56.0 | as a kid. It was like the most meaningful thing for me. For us old guys. Yeah. It strikes a quote. |
| 1:01.6 | Yeah. All right. Listen, we have so much to get to. It's A.070, by the way. I've started |
| 1:07.4 | keeping track again. Good. AO 70. 70 days since our very first episode about OpenClaw. |
| 1:14.0 | A070, yeah. |
| 1:15.0 | And I got a confession here. |
| 1:20.1 | This week in startups is brought to you by Shopify. |
| 1:23.5 | Turn those what-ifs into sales with the e-commerce platform powering millions of businesses. |
| 1:28.6 | Sign up for your $1 per month trial today at Shopify.com slash twist. |
| 1:33.8 | Vanta. |
| 1:34.4 | Compliance and security shouldn't be a deal breaker for startups to win new business. |
... |
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