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Tetragrammaton with Rick Rubin

Andrew Huberman, Ph.D. (Part 2)

Tetragrammaton with Rick Rubin

Rick Rubin

Arts, Society & Culture, Philosophy

4.61.2K Ratings

🗓️ 19 September 2025

⏱️ 102 minutes

🧾️ Download transcript

Summary

Dr. Andrew Huberman returns to continue his conversation in Part Two. Dr. Andrew Huberman is a neuroscientist and tenured professor of neurobiology, psychiatry, and behavior sciences at Stanford School of Medicine. His research centers on brain development, neural plasticity, and how vision and respiration shape human performance and cognitive function. Beyond his work in academia, Huberman is the creator and host of the Huberman Lab podcast, the world’s leading health podcast, where he shares science-based insights on brain and body optimization.Exploring how to improve mental and physical health alike, he is also the author of the upcoming book Protocols: An Operating Manual for the Human Body. ------ Thank you to the sponsors that fuel our podcast and our team: LMNT Electrolytes https://DrinkLMNT.com/tetra Use code 'TETRA' ------ Athletic Nicotine https://www.AthleticNicotine.com/tetra Use code 'TETRA' ------ Squarespace https://Squarespace.com/tetra Use code 'TETRA' ------ Sign up to receive Tetragrammaton Transmissions https://www.tetragrammaton.com/join-newsletter

Transcript

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0:00.0

Tetragrammaton So I've talked a little bit in the past, although not much.

0:28.2

I was part of a clinical trial for MDMA, so-called ecstasy.

0:33.6

A lot of people don't realize this, but it's methylene-dioxy, methamphetamine.

1:01.0

It's a weird drug because, first of all, it's completely synthetic. It doesn't exist in nature. When was it created, do you know? For the first time, I think it was created in like 1913 by Merck or something like that. I'm probably the date and the company wrong, but sometime around that. It's an old drug. Then it wasn't touched again. And then a guy named Sasha Shulgin and his wife, living in Berkeley, California, made it. Sasha and his wife would make compounds and give it to their friends, all these therapists

1:05.0

in the Bay Area, at a time when the Bay Area was still hit.

1:08.0

There is cool, but it's not as adventurous as it used to be. Maybe there's a new

1:13.8

generation, but so Shulgin would make these drugs, give them to his therapist friends, they would take

1:20.0

them and then they'd take notes. He actually wrote a book as the worst name of any book. It's called

1:24.4

Peekal. P-I-K-H-A-L. Phenal-ethyl-A-means I have known and loved.

1:32.4

Dumbest name ever for a book if you want people to read the book. In any case, MDMA,

1:38.2

Exstasy is not a plant medicine. It's also not a psychedelic, but it's what's called an

1:42.2

empathogen. And it has a very interesting

1:44.6

property. What's an empathogen? An empathogen is a molecule that makes you feel more empathic

1:49.8

for yourself or others, basically anything you focus on. This is the one, well, there's several,

1:54.7

but this is the one danger of MDMA, which is that unless you have someone to guide you,

2:00.6

you can fall in love with water on MDMA, which is that unless you have someone to guide you, you can fall in love with

2:02.3

water on MDMA.

2:05.1

Is that bad?

2:06.1

No, but it's the waste of some potentially more useful therapeutic time.

2:13.1

You can really start to develop a relationship to anything you place your sensory focus on.

2:18.3

So I think in general, used as a tool for like PTSD, where you're developing empathy for yourself,

2:24.3

or maybe even for your oppressor, that happens too, where people forgive themselves and others.

...

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