Andrew Huberman, Ph.D. (Part 1)
Tetragrammaton with Rick Rubin
Rick Rubin
4.6 • 1.2K Ratings
🗓️ 17 September 2025
⏱️ 92 minutes
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| 0:00.0 | Tetragrammaton Learning about cortisol and what it actually does completely revamped the way I think about everything, health-wise, and it basically put things into bins that make it all make a ton more sense. |
| 0:40.9 | Because I, like most people, heard everything bad about cortisol. |
| 0:45.4 | It's like cortisol is a stress hormone. |
| 0:48.8 | It's not true, actually. |
| 0:51.1 | Cortisol's job is not to combat stress. |
| 0:53.5 | Cortisol's job is to cause the release of energy from your muscles, from your liver, so your brain and muscles have energy. |
| 1:02.0 | Yes, to combat stress if there's something stressful. |
| 1:05.0 | But the reason you wake up in the morning or in the middle of the night is because of a normal increase in cortisol, a healthy |
| 1:11.7 | increase in cortisol. It's called the cortisol awakening response. In all my years of learning |
| 1:16.2 | about neuroendocrinology, no one bothered to tell me that, but it's in the textbooks. It's just |
| 1:22.7 | kind of hidden there. Cortisol's job is to create energy for the brain and body. If its levels get high enough, |
| 1:29.4 | you wake up from your sleep. And so when you take a step back and go, okay, what do cortisol |
| 1:35.4 | levels look like across the day? It's basically your cortisol wakes you up in the morning |
| 1:40.8 | because it's rising and that ing is important not because it hits a |
| 1:45.5 | certain level because it's the slope is steep then after you wake up your cortisol continues to |
| 1:51.7 | rise and you want your morning cortisol really high this is what no one will tell you everyone's like |
| 1:57.8 | gutted kid cortisol nuke your memory cortisol makes you lose neurons. That's a separate issue. There are contexts where that's true. |
| 2:06.4 | But basically, in the first hour after waking, you have a unique opportunity to spike your cortisol |
| 2:11.8 | even higher, and that's what you want to do. Because if you do that, you set up a wayfront |
| 2:17.0 | of energy through the morning |
| 2:18.3 | for alertness, for focus, and it makes sure that your cortisol is low in the evening and at night, |
| 2:25.2 | which is also what you want. If you don't get your cortisol high enough in the morning, |
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