Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity
The a16z Show
a16z
4.2 • 1.2K Ratings
🗓️ 9 March 2026
⏱️ 52 minutes
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| 0:00.0 | You don't want to stimulate the sympathetic nervous system so much for so often. It can probably shorten your life. There's a whole category of what are called growth hormone secretagogues, which are very popular. People here are erection, fat loss, energy, tan, like, oh, great. This isn't the kind of thing you do to like go on vacation. You've got to be real careful with these things. Nearly one in seven Americans is taking a GLP1 drug. 20% have tried them. What do you think the future looks like? |
| 0:24.2 | In theory... with these things. Nearly one in seven Americans is taking a GLP one drug. 20% have tried them. |
| 0:22.4 | What do you think the future looks like? In theory, you could eradicate obesity. People can lose up to |
| 0:27.2 | a third of their body weight. Melanatanatan, which makes people tan from the inside, raises energy |
| 0:32.6 | and libido dramatically, fat loss dramatically. BPC 157, body protection compound. |
| 0:38.3 | It's not legal, but it's not necessarily enforced. |
| 0:40.3 | They list them as for research purposes only not for human use. |
| 0:44.3 | I mean, who's doing research on these peptides at home? |
| 0:46.3 | Any time you're stimulating cell growth, it could start going awry and then get a tumor or something like that. |
| 0:51.3 | If that's within your margins of risk, that's up to you. |
| 0:54.9 | I want to talk about what's happened over the last five years. |
| 0:58.1 | Slowly through the 80s, through the 90s, and then the early 2000s, |
| 1:02.1 | everyone wanted to know what they could take to improve their immune system and their health. |
| 1:06.3 | There's a very interesting drug I think is going to become far more popular soon, which is... |
| 1:15.6 | When the pandemic hit, people wanted to know what they could take to protect themselves. The first thing that broke out was vitamin D, innocuous enough that doctors didn't push back. |
| 1:20.6 | That cracked the door open. Then resistance training went mainstream, |
| 1:23.6 | bringing with it at interest in protein, creatine, and caffeine. |
| 1:32.6 | The vaccine debate got heated, the evening news health segment lost credibility, and a realization set in, we are all responsible for our own health. Now the conversation has moved well-past |
| 1:37.7 | supplements. Reduxutide could reshape obesity. Peptides are circulating through compounding |
| 1:42.9 | pharmacies and gray markets. |
| 1:44.7 | And we may be approaching the point where we stop just reading our biology through wearables |
| 1:48.5 | and start writing to it, using neurototechnologies that control sleep, focus, and cortisol |
... |
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