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🗓️ 4 August 2025
⏱️ 31 minutes
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L-Glutamine stands as one of the most powerful amino acids for optimizing gut health, muscle function, immune and brain health. It’s a common solution for leaky gut, but overall can enhance the improvement of other therapies. In this episode, I’ll dive into the benefits of l-glutamine, the best food sources, and effective protocols for different conditions.
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L-Glutamine Powder: https://store.drruscio.com/products/glutamine-powder
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👇 Watch more videos like this 👇
➡️This Leaky Gut Diet Fixes the Root Cause of Poor Gut Health:
https://www.youtube.com/watch?v=6wk9GaT2mtw
➡️The 4 MOST Effective Leaky Gut Treatments:
https://www.youtube.com/watch?v=MW1ezm3d0JQ
➡️A Simple & Effective Leaky Gut Repair Protocol:
https://www.youtube.com/watch?v=5en_twP8DcE
➡️The 10 BEST Foods for Leaky Gut:
https://www.youtube.com/watch?v=f5yXO71ZDec
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👇Read these next 👇
➡️How To Heal Leaky Gut:
https://drruscio.com/how-to-heal-leaky-gut/
➡️Best Vitamins for Gut Health: How to Support Your Gut Microbiome:
https://drruscio.com/vitamins-for-gut-health/
➡️8 Best Microbiome Supplements for a Happier, Healthier Gut:
https://drruscio.com/best-microbiome-supplements/
➡️ Probiotics and 5 Other Leaky Gut Supplements to Help You Heal:
https://drruscio.com/leaky-gut-supplements/
00:00 Intro
01:47 Are you getting enough glutamine?
03:59 Gut benefits
11;53 Immune benefits
15:38 Brain benefits
17:29 Muscle benefits
19:40 Recommended protocol
21:49 Adverse effects
📉Glutamine in the Complex Interaction between Gut Microbiota and Health: https://pubmed.ncbi.nlm.nih.gov/31652531/
📉Glutamine Supplementation in Human Exercise and Sport Training:
https://jn.nutrition.org/article/S0022-3166(22)09697-3/fulltext
📉Dietary glutamine supplements for postinfectious IBS:
https://pubmed.ncbi.nlm.nih.gov/30108163/
📉Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in IBS Management:
https://pubmed.ncbi.nlm.nih.gov/34977110/
📉Glutamine supplementation on IBD: https://pubmed.ncbi.nlm.nih.gov/33745622/
📉Glutamine metabolism & optimal immune and CNS function:
https://pubmed.ncbi.nlm.nih.gov/36285520/
📉Therapeutic benefits of glutamine: https://pubmed.ncbi.nlm.nih.gov/28529738/
📉Glutamine on Immune Function & Post-Operative Complications of Patients With Colorectal Cancer:
https://pubmed.ncbi.nlm.nih.gov/34938760/
📉Supplementation of L-glutamine enhanced mucosal immunity & improved hormonal status of combat-sport athletes: https://pubmed.ncbi.nlm.nih.gov/38193521/
📉Glutamine supplementation on athletic performance, body composition, and immune function:
https://www.clinicalnutritionjournal.com/article/S0261-5614%2818%2930173-0/abstract
📉Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans: https://pubmed.ncbi.nlm.nih.gov/32688366/
📉Oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men: https://link.springer.com/article/10.1007/s00394-022-02806-1
📉Glutamine supplementation on gut permeability in adults: https://pubmed.ncbi.nlm.nih.gov/39397201/
📉Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease:
https://pubmed.ncbi.nlm.nih.gov/22038507/
📉Albendazole therapy and enteric parasites in United States-bound refugees:
https://pubmed.ncbi.nlm.nih.gov/22512482/
📉Glutamine metabolism and optimal immune and CNS function:
📉Glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: https://pubmed.ncbi.nlm.nih.gov/34709541/
📉DIetary supplements on markers of exercise-associated gut damage and permeability: https://pubmed.ncbi.nlm.nih.gov/35417467/
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g
*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.
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0:00.0 | Welcome to Dr. Rucho Radio, providing practical and science-based solutions to feeling your best. |
0:14.8 | To stay up to date on the latest topics, as well as all of our prior episodes, make sure to subscribe in your podcast player. |
0:22.2 | For weekly updates, visit Dr.ruciot.com. |
0:26.3 | Glutamine is considered a non-essential amino acid, but that doesn't tell the whole story. |
0:31.3 | Under times of stress, your body cannot produce enough glutamine to meet its demands. |
0:38.3 | And this is fairly widely acknowledged. |
0:40.3 | I'll lead with a quote here. |
0:42.4 | During severe metabolic stress, more glutamine must be produced and released to meet increased |
0:47.7 | metabolic demands for rapidly dividing cells such as gut and immune system. |
0:54.1 | Normally, our body can, again, produce enough glutamine. |
0:58.5 | This is why it's considered non-essential. Your body can synthesize it to meet the demands. |
1:03.5 | And the glands that are predominantly in charge of said production include liver, skeletal muscle, |
1:10.0 | lungs, and fat cells. And the users, the tissues |
1:14.2 | that require the glutamine that soak up and metabolize glutamine, include brain, gut, and |
1:21.3 | immune cells. Now, what happens during periods of stress? And stress can be psychological stress, but also metabolic |
1:29.1 | stress includes chronic inflammation, infection, tissue injury. So under these situations, |
1:39.8 | now there is no longer enough synthesis, and what ends up happening is consumption outpaces synthesis |
1:49.5 | and we start to see deficiencies in these key tissues including the gut, the immune system, |
1:58.3 | and the brain. And this is why glutamine has also been described |
2:03.3 | as a conditionally essential amino acid, |
2:06.3 | meaning during periods of stress, |
2:09.2 | the body needs more than is typically able to be produced. |
... |
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