603- The Brain Chemistry of ADHD: Understanding Dopamine, Serotonin & Norepinephrine
ADHD Experts Podcast
ADDitude
4.4 • 1.4K Ratings
🗓️ 28 April 2026
⏱️ 61 minutes
🧾️ Download transcript
Summary
Gregory W. Mattingly, M.D., provides an overview of the key neurotransmitter systems — particularly dopamine, norepinephrine, and serotonin — that contribute to the core features of ADHD, and the medications used to treat the condition.
Resources: ADHD & Brain Health
- Free Download: Unraveling the Mysteries of Your ADHD Brain
- Read: ADHD Neuroscience 101
- Read: Everything You Never Knew About the ADHD Brain
- Read: Using a Dopamine Menu to Stimulate Your ADHD Brain
Access the video and slides for podcast episode #603 here: https://www.additudemag.com/webinar/brain-chemistry-dopamine-serotonin-norepinephrine-adhd/
This episode is sponsored by the podcast Hyperfocus with Rae Jacobson. Search for "Hyperfocus with Rae Jacobson" in your podcast app or find links to listen at https://lnk.to/hyperfocusPS!adhdexperts.
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Transcript
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| 0:00.0 | Welcome to the Attention Deficit Disorder Expert Podcast series by Attitude Magazine. |
| 0:13.9 | Hello, everyone. |
| 0:15.4 | I am Annie Rogers from Attitude, and today I'm so pleased to welcome you to our ADHD |
| 0:20.7 | expert's presentation |
| 0:22.1 | titled The Brain Chemistry of ADHD, Understanding Dopamine, Serotonin, and Norophenaphrin. |
| 0:30.4 | Leading today's presentation is Dr. Greg Mattingly. Dr. Mattingley has been a psychopharmacology |
| 0:37.3 | instructor for more than 20 years at the Washington |
| 0:40.4 | University School of Medicine in St. Louis, Missouri. Dr. Mattingly earned his medical degree in |
| 0:46.1 | residency at Washington University, where he received a full Bright scholarship. He's been a principal |
| 0:51.6 | investigator in more than 500 clinical trials, and his research has been published in numerous national and international journals. |
| 1:01.3 | He is the CMO for Acumen Neuroscience, a research insights and analytics company. |
| 1:08.0 | In addition to his clinical and research practice, Dr. Mattingly has worked as a mental |
| 1:12.6 | health consultant and evaluator for both the National Football League and Major League Baseball. He is |
| 1:19.6 | the past president for the American Professional Society of ADHD and Related Disorders |
| 1:25.2 | or Apsard and serves on the Scientific Program Committee for the World |
| 1:29.9 | Federation for ADHD and is co-chair for the U.S. Psych Congress. |
| 1:35.1 | Dr. Mattingly is one of the world's foremost experts in ADHD, and we are extremely fortunate |
| 1:40.6 | to welcome him here today. |
| 1:43.3 | As you all know, ADHD is not a disorder of willpower. |
| 1:47.9 | It is a condition of dysregulation. Decades of neurobiological research confirmed that |
| 1:53.3 | altered signaling in key neurotransmitter systems, particularly dopamine, neuropinephrine, and |
| 1:59.3 | serotonin, contribute to the core features of ADHD, |
... |
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