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From CNN, I'm Fez Jamil with the five things you need to know for Wednesday, April 17th.

The U.S. will impose new sanctions targeting Iran after its large-scale attack on Israel

over the weekend.

National Security Advisor Jake Sullivan says the sanctions will target the

country's missile and drone program and other entities of Tehran's defense programs.

Sources tell CNN the U.S. now expect entities of Tehran's defense programs.

Sources tell CNN the U.S. now expects Israel's response

to be limited in scope, as CNN's Nada Bashir explains.

At this stage, no clear details around the timing, perhaps location of this attack, but certainly

concern around what this could mean in terms of potential retaliation from Iran. but of course there is a continued push for all parties to focus on the diplomatic front, to return to the diplomatic table.

The Senate is set to review and likely dismiss the impeachment trial of Homeland

Security Secretary Alejandro Mayorkas today. He is the first Cabinet Secretary to be impeached

in nearly 150 years, but the Democrat-controlled

chamber is expected to quickly drop the charges or hold a short trial that won't lead to a

conviction.

House Republicans voted by a narrow margin to impeach him two months ago

...