#495: Circadian Clocks in Muscle & Exercise as a Time Cue – Prof. Karyn Esser
Sigma Nutrition Radio
Danny Lennon
4.8 • 633 Ratings
🗓️ 12 September 2023
⏱️ 35 minutes
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Summary
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About this Episode:
The field of circadian biology has long been associated with regulating diurnal physiological processes, notably the sleep-wake cycle. However, recent advances have unveiled a broader role for circadian clocks across various tissues, including skeletal muscle.
Within this context, the investigation of circadian clocks within the skeletal muscle milieu has emerged as a frontier of scientific inquiry. These intrinsic timekeeping mechanisms exhibit multifaceted regulatory capacities beyond mere temporal synchronization.
This episode delves into the implications of "circadian clocks" operating within skeletal muscle tissue, with the esteemed Prof. Karyn Esser as this week's guest. Her pioneering work has been instrumental in understanding the interplay between circadian rhythmicity and muscular physiology.
Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. This is episode 495 of the podcast. You are very welcome. My name is Danny Lennon, |
| 0:23.3 | and yet again we're going to be having a discussion all about evidence-based health, nutrition, |
| 0:29.1 | etc. on today's show. And today I'm going to be talking with Professor Karen Esser, |
| 0:34.1 | who is the chair of the Department of Physiology and Aging at the University of Florida. |
| 0:40.1 | And Professor Esser was among the very first researchers to recognize the importance of circadian |
| 0:45.3 | rhythms to cell and muscular health specifically. In fact, it was Professor Esser's lab that |
| 0:51.7 | pioneered a lot of the research looking at the role of circadian |
| 0:55.6 | rhythms and in particular the molecular clock mechanism in skeletal muscle homeostasis |
| 1:01.2 | and muscle function and muscle health. |
| 1:04.6 | And her work has shown a number of really interesting things, particularly in relation to |
| 1:09.3 | mutations that happen in two different molecular |
| 1:11.7 | clock genes and how that can really disrupt muscle structure and muscle function. |
| 1:17.6 | And much of her recent work over the last number of years has been looking at the role |
| 1:21.9 | of physical activity or exercise as a potential time queue for the clocks that are found in muscle, as well as some |
| 1:30.6 | other tissues. And some of this work has been really interesting, showing that the time of exercise |
| 1:36.0 | could have this impact on that clock mechanism. And that's also independent of things like light |
| 1:42.0 | exposure or even of the central clock. But we'll come to that |
| 1:45.6 | throughout this conversation, no doubt. So if you have listened to any of our previous episodes |
| 1:50.7 | that are related to chronobiology, chrononutrition, etc, I think you're going to find this |
| 1:56.4 | really nice adjunct. And if you haven't, don't worry. You'll be able to jump straight into this |
| 2:01.2 | episode. You get hopefully a lot of really interesting stuff from it. And then that will also connect |
| 2:05.7 | back to some of our previous episodes if you do wish to go back through our catalog and |
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