#494: Multiple Risk Factor Intervention Trial

Sigma Nutrition Radio

Danny Lennon

Nutrition, Health & Fitness

4.8 • 633 Ratings

🗓️ 5 September 2023

⏱️ 55 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Links:

About This Episode:

The Multiple Risk Factor Intervention Trial (MRFIT) was a groundbreaking clinical trial conducted in the 1970s and 1980s. Its main objective was to investigate the relationship between various risk factors and the incidence of heart disease.

The study aimed to determine whether modifying risk factors, such as high blood pressure, high cholesterol levels, and smoking, could lead to a reduction in cardiovascular events.

The trial spanned several years, with participants being followed up for a period of approximately six years to assess the incidence of cardiovascular events and mortality. The primary outcome measures included coronary heart disease (CHD) mortality and overall mortality.

The MRFIT trial yielded several important findings that have significantly influenced our understanding of cardiovascular health and prevention strategies.

In this episode we take a look at why this is such seminal research, as well as the contribution of one of the greatest researchers ever in the field, Jeramiah Stamler.

Transcript

Click on a timestamp to play from that location

0:00.0	Hello and welcome to Sigma Nutrition Radio. This is episode 494 of the podcast. My name is Danny Lennon and with me is Dr. Alan Flanagan.
0:24.6	Alan in the recent weeks or maybe months past, depending on when people are listening to this,
0:29.3	you've had another one of your papers published. And I know this was a particular one that
0:34.0	had a lot of personal interest to you and ticked a lot of boxes of this
0:38.7	interesting thought process between nutrition science but also epistemology and how we can do
0:44.9	better methodology going forward so first congratulations on the publication of the paper and then
0:49.8	second maybe let people know a bit about that and how the paper came about and some of the ideas that you wanted to put into it.
0:56.0	Yeah, thanks. It was nice to get it. So it was published in BMJ Nutrition Prevention and Health. It's open access.
1:03.0	And it was really great to, we talk a lot on this podcast about methodology and some of the epistemic considerations for nutrition
1:14.9	and this question over research design and how can we come to know what we know and certainly
1:23.6	factors that we've discussed before like common criticisms of nutrition for example
1:28.9	a reliance on epidemiology or is that reliable should we as a field just be
1:35.9	conducting just more randomized control trials would that produce a better
1:39.7	evidence base and it was written in collaboration with Ned Pro, the Global Institute for Food
1:46.1	and Nutrition and both senior authors, Professor Shimon Ray and Martin Colmire, and our other
1:53.8	author, James Bradfield, were all, and myself included, involved with NetPro. Indeed,
1:59.6	Shimon is the chairman of NetPro.
2:01.9	So the paper really set out, it's Ned Pro's 15th year anniversary.
2:06.4	It's also the five-year anniversary of the launch of BMJ, MPH.
2:11.3	The paper was an invited submission where we sought to try and detail some of these questions over the viability
2:22.3	and reliability of nutrition, trying to specifically address some common criticisms that were made.
2:30.2	And one in particular was if you really look in close detail at the claims that, for example,
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Danny Lennon, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Danny Lennon and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.