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The Dr Louise Newson Podcast

47 - Rethinking mental health and antidepressant prescribing

The Dr Louise Newson Podcast

Dr Louise Newson

Health & Fitness, Medicine

4.7933 Ratings

🗓️ 17 February 2026

⏱️ 36 minutes

🧾️ Download transcript

Summary

Content advisory: this episode contains themes of metal health and suicidality

In this episode, Dr Louise Newson is joined by Dr MarkHorowitz, who is a psychiatrist, researcher and world-leading expert in psychiatric medication withdrawal and deprescribing. Mark is also the lead author of the Maudsley Deprescribing Guidelines and co-founder of Outro Health, the only virtual clinic in the United States offering a clinically validated antidepressant tapering service.

Together, they explore how antidepressants,gabapentinoids and other psychoactive medications became so widely prescribed and why stopping them is often far more difficult than starting them. Thediscussion looks closely at what the evidence actually shows about effectiveness, long-term risks, withdrawal effects and suicidality, particularly for women and younger people.

The conversation also examines how hormonal changes, life stressors and social factors are frequently overlooked, leading to the medicalisation of distress that may be a normal response to difficultcircumstances.

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Transcript

Click on a timestamp to play from that location

0:00.0

Mark Horowitz is on my podcast today, and this is actually going to blow your mind.

0:05.8

You might have to listen to it more than once.

0:08.2

We talk about antidepressants, we talk about benzodiazepines, we talk about gabapentinin,

0:14.5

progabalin, these highly addictive drugs that are prescribed more commonly than HRT and have more risks with them.

0:22.8

We need to be thinking differently about mental health. And his perspective on things,

0:27.3

including his research, is really interesting. And I just hope it makes you think of it

0:32.4

differently. So Mark, this is great that you've come in today. I know it's going to be a very interesting

0:39.4

podcast that's going to resonate with a lot of people. People might be wondering why I'm

0:44.0

holding such a big, heavy book that I've slugged across London, but it's the Maudsley

0:48.8

deprescribing guidelines, antidepressants, benzodiazepines, gabapentinoids, which is gabapentin and progabalin, and

0:57.3

Zed drugs, which are the sort of Zopachlone sleeping tablets. And you are a co-author of this. And

1:03.8

you've written so many papers. Your knowledge is huge and I just wanted to get as much out of your

1:10.7

lovely brain for the next half an hour.

1:13.2

So just before we start, though, just explain a bit about your background if you don't mind, Mark.

1:17.1

Thanks having me on.

1:18.0

And if the book is heavy to carry, imagine how hard it was to write.

1:21.4

So thank you.

1:23.0

So I'm Mark Horowitz.

1:24.5

I'm a training psychiatrist and researcher.

1:27.4

I'm an associate professor of psychiatry at Adelaide University and I'm a Horowitz. I'm a training psychiatrist and researcher. I'm an associate professor of

1:29.2

psychiatry at Adelaide University, and I'm a visiting lecturer in psychopharmacology at King's College,

1:34.1

London. And I run a deprescribing clinic that's specialised in helping people to stop

...

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