#444: Folate – Intake, Genetics & Health Outcomes

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 28 June 2022

⏱️ 73 minutes

🔗️ Recording | iTunes | RSS

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Summary

Folate (also known as viatmin B9) actually relates to a collection of folates; both natural dietary folates and synthetic forms, primarily folic acid. This folate/folic acid that is consumed via the diet or supplementation is a precursor for the formation of tetrahydrofolate (THF), which is a carbon donor and acts a cofactor for a number of enzymes that play important roles in several processes.

In this episode, Alan and Danny discuss the role of folate in the methlyation cycle, the impact of folate insufficiency/deficiency, genetics variatnts of the MTHFR gene (and other genes) that impact folate metabolism, and the impact of folate on health outcomes; including heart disease, birth defects, cancer, and brain health & cognition.

Detailed study notes and transcript to this episode

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0:00.0	Hello and welcome to the podcast. This is Danny Lennon, and you're very welcome to Sigma Nutrition
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0:57.4	And so with that, let's dive into this episode.
1:18.6	Hello. Hello and welcome to another episode of Sigma Nutrition Radio.
1:22.8	This is episode 444 of the podcast.
1:26.8	My name is Danny Lennon and I'm here with Alan Flanagan.
1:28.3	Alan, how are you, sir? I am very good, thank you.
1:30.8	I'm now no longer just a candidate for a PhD.
1:36.3	So it's nice to be over the line.
1:38.3	Yeah, a big congratulations are in order.
1:41.8	Big congratulations and we'll certainly maybe touch on some of what came out of that PhD and some of your publications at a later time point. But for today, we're going to be talking all about folate. And there's a number of interesting avenues for us to explore throughout this conversation. We're going to be talking about folate, some of the metabolism of
2:01.6	that, how it's involved in various processes in the body, we'll be looking at folate deficiency,
	...

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