#443: Kevin Klatt, PhD, RD - Can Choline Help Improve DHA Status?
Sigma Nutrition Radio
Danny Lennon
4.8 • 626 Ratings
🗓️ 22 June 2022
⏱️ 71 minutes
🧾️ Download transcript
Summary
We discuss:
- What is the connection between choline and DHA? What is the PEMT pathway?
- Study design for the choline + DHA trial
- Are there risks of high-dose choline?
- Main findings of the trial
- How DHA status is not just a function of DHA intake, but also methyl metabolism too
- Issues with omega-3 trials; e.g. not taking baseline status into account
- Pragmatic recommendations for health professionals and patients
- Different forms of choline supplements
- Choline supplementation vs. food-derived choline
Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. This is episode 443 of the podcast, and I am your host, Danny Lennon. You are very |
| 0:24.1 | welcome to the podcast. Today I'm going to be talking with Dr. Kevin Klat, all about coline, DHA, |
| 0:31.8 | and particularly its impact on DHA status, potentially in pregnancy. And this all comes off the back of a recently |
| 0:39.2 | published study that was done by Dr. Klat and his colleagues that examined the impact of |
| 0:44.8 | Koline supplementation alongside DHA supplementation on DHA status during pregnancy. Now, if you're a |
| 0:52.2 | regular distances podcast, you will have heard us talk all about |
| 0:55.1 | how critical of a nutrient DHA is at this time for the healthy development of the fetus. |
| 1:01.9 | So through a number of mechanisms, it may now be possible that coline could have an important |
| 1:08.4 | role to play in leading to greater DHA status or greater DHA |
| 1:13.0 | availability to actually get to fetal tissues. And we're going to mention more of that |
| 1:18.2 | throughout this conversation. So we're going to dive in all into that stuff and including |
| 1:22.7 | specifically into this recently published trial. Now, as a brief bit of background, Dr. Clatt is a nutrition researcher, registered dietitian, |
| 1:31.3 | and he has completed his doctoral work in nutrition at Cornell University. |
| 1:36.3 | He did his dietetic training at the National Institutes of Health or the NIH, |
| 1:40.3 | and then spent time as a researcher at Baylor College of Medicine and has currently now based |
| 1:45.2 | himself at UC Berkeley in California. Much of his research expertise lies in lipids, one carbon |
| 1:52.4 | metabolism, which we'll discuss later on in this podcast, nuclear receptors, and then nutrient |
| 1:57.5 | roles in pregnancy. In addition to that research, Dr. Clatt is also the young career editor at the American Journal of Clinical Nutrition. |
| 2:05.6 | Now, this is an episode where we're going to get quite deep at times, |
| 2:09.6 | particularly into some of the metabolism and what actually goes on with DHA and coline when they are consumed, and the fate of those within the body will bring |
| 2:19.7 | up certain types of pathways. And so this in particular will be maybe a great episode for |
| 2:27.2 | people to access the detailed study notes that we provide for those of you who are listening |
... |
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