Hello and welcome to Sigma Nutrition Radio. As ever, I'm your host, Danny Leiden. We are at episode

396 of the podcast today, and I'm

absolutely delighted to be joined by Dr. Lee Frame, who is Director of Integrative Medicine

at George Washington School of Medicine and Health Sciences, based in Washington, D.C.

And she has a diverse background in a range of different nutrition science and health

science areas. But today we're going to focus in specifically on randomized control trial

design within nutrition supplementation trials and really look at specifically ethics and how

that impacts some of the trial design and also

a specific focus in on the use of placebo groups, which is something that Dr. Frame has written

really eloquently on in the past. And I wanted to kind of dive into this area because I think

it's really useful to start trying to think through how trials can

be more appropriately designed, but also when we look at placebo groups and other aspects of

the trial design, how that might actually impact the results we're getting from a study and

just gives an extra layer of critical thinking for those who do regularly read research papers.

So I hope you find this particularly interesting.

The show notes this episode are going to be over at sigmautrition.com

slash episode 396.

So if you go there, you can get a transcript to this episode.

You'll get links to any relevant research papers we mentioned or other resources,

as well as more about Dr. Frames's background. So that's all at sigmautrition.com

slash episode 396. And whilst you're on the Sigma Nutrition website, check out some of our

other resources, including all our written content, including our Sigma statements, which are

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