34 EPIC
Veterinary Clinical Podcasts
Dominic Barfield
5.0 • 643 Ratings
🗓️ 3 November 2016
⏱️ 44 minutes
🧾️ Download transcript
Summary
In this podcast we talk to one of the principle investigators of the EPIC study, Professor Adrian Boswood. We discuss the findings of the evaluation of pimobendan in dogs with cardiomegaly caused by preclinical mitral valve disease. Why not go to the Journal of Veterinary Internal Medicine’s website, download it and have a read now! http://onlinelibrary.wiley.com/doi/10.1111/jvim.14586/full
It is not often that a single paper has the ability to radically change clinical practice. This epic study has overwhelming evidence that pimobendan administration before the onset of clinical signs in dogs with mitral valve disease (MVD) prolongs the preclinical period by 15 months. The dogs were identified by having a ≥3/6 grade systolic heart murmur, echocardiographic evidence of MVD, and radiographic or echocardiogram evidence of cardiomegaly.
You can also see a video of Professor Boswood discussing this study on youtube https://www.youtube.com/watch?v=wtzr1E3V-gE and an infographic too https://www.youtube.com/watch?v=5qxHMGZ-9aU
It is indeed EPIC.
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Transcript
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| 0:00.0 | Welcome to the RVC clinical podcast. My name is Dominic Barfield and today we're going to talk about the |
| 0:04.4 | epic study hot off the press. It's great that veterinary studies are latching onto the catchy |
| 0:09.0 | names in the medical field given to study names. The epic study is looking at the effect of Pimabendan |
| 0:14.3 | in dogs with preclinicinic, mitral valve disease and cardiomegaly. So this paper has been published |
| 0:20.3 | in the Journal of Veterinary |
| 0:21.1 | Internal Medicine, and with all their publications, their open access, which means you can log on to |
| 0:25.6 | any computer in the world and go to the Journal of Veterinary Internal Medicine website and retrieve |
| 0:29.4 | this article. So I encourage you to go and read it. You could even pause this podcast now, go to the |
| 0:34.5 | site, download it, and have it to read in front of you. So today I'm |
| 0:38.2 | joined by Professor Boswood, lead author of the paper with the other heavyweights in the |
| 0:42.6 | verticombolecoments of the veterinary cardiology world. So good afternoon, Professor, and thank you for |
| 0:46.4 | letting me press on you into having a chat today. Pleasure and good afternoon to you as well. |
| 0:51.9 | First of all, I'd like to say congratulations on orchestrating |
| 0:54.6 | contributing and panning this study as it's obviously a huge endeavour which |
| 0:59.8 | recruitment to the study began six years ago this month that's right I believe and in |
| 1:04.8 | particular collaborations across different centres in different countries it must |
| 1:08.3 | been very difficult to wrangle that number of cardiologists because I struggle to wrangle any cardiologists within our own institution. |
| 1:16.8 | It was a great challenge, but at the same time also a great privilege to be able to lead a group |
| 1:25.0 | like that. Necessarily, when the study was beginning, it meant that we had to |
| 1:31.1 | get everyone together, discuss the protocol, get everyone to agree. And clearly, the larger the number of |
| 1:38.6 | people involved, the less likely it is that everyone will agree. But we, in the end, we all decided we were happy to proceed |
| 1:46.1 | with the study and I'm very glad we did. Excellent. Excellent. So can I first ask Professor Boswood, |
... |
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