313. Marathons v. Ultras, Fatigue Resistance Debates, Gene Editing Breakthrough, and Posture Impact on Blood Volume!
Some Work, All Play
David Roche and Megan Roche
4.8 • 2.1K Ratings
🗓️ 2 June 2026
⏱️ 94 minutes
🧾️ Download transcript
Summary
We put some cinder blocks under the head of our bed (for science!) before this great episode. A weird study just came out finding that head-up sleeping may increase red blood cell totals. We talk about what it means and what it doesn’t mean. Excuse us while we launch a cinderblock start-up.
We also discussed a breakthrough in gene editing for cholesterol, and what that could mean for the future. The world is going to be so different in 50 years! Maybe by then, David can use CRISPR to be able to pronounce science words.
And this one was full of fun topics! Other topics: our training log discussions, iron levels in athletes, breaking news on heat training from Unbound 200, a science debate on fatigue resistance terminology, and a study on glucose v. fructose.
Plus, we answer questions on heat training in the car, clean sport for age group athletes, marathon v. ultra training, and health uncertainty.
You’re going to learn a lot about what Megan would do for 40 grams of carbs. Totally normal stuff if you ask her!
We love you all! HUZZAH!
-David and Megan
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Transcript
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| 0:00.0 | Woohoo. Welcome to the Some Work All Play podcast. We are so happy with you today. Happy Tuesday. It's |
| 0:05.2 | Tuesday. And I'm refreshing my training logs on this Tuesday. Oh shit. Training logs. Yeah, we're doing that. I'm refreshing all the time for yours. Oh yeah. You bring me so much joy in your training log. What do you mean by that? I update it all the time because your updates and there are fire. They're so good. They're so funny. |
| 0:21.4 | Also, it's like 24 ways to get you canceled. Oh, yeah, yeah, yeah. I'm just trying to make you laugh every day. You really do. And I'm giving you like ammo if we ever go to divorce court. You're going to just be able to be like, here's the training log. Look what he's writing. Yeah, the judges can make, yes, you are the brains of the operation for sure. |
| 0:38.7 | We should maybe put a security code on it just so no one hacks into it. Yeah. I mean, it's legitimately 24 ways to get you kids. That's actually very true. And you read about the Claude Mythos, their new model that they leaked out just some people to show, oh, wait, all of your security is not adequate for this |
| 0:55.8 | next generation of model. I've panicked about that a lot because I'm that type of guy that |
| 1:00.1 | uses the same password for everything, as you know. Same. Yes. And both of ours are very |
| 1:04.7 | guessable. Yeah. And we basically use the same passwords as each other. So we're very, very hackable. |
| 1:10.3 | That's actually scary. Why are we |
| 1:11.4 | putting this on the podcast? I know. Actually, I was like, someone, someone's going to try this out there. That's scary. Well, hopefully no one has called Mythos access that's listening to this podcast. But it is so fun to be in your training log as you come back to an 11 hour training week last week. Yeah, coming back from my heart, feeling good. I created a trading log too because it's |
| 1:31.1 | nice to be accountable for some of the chest pain that I was experiencing before. I was like, I need to document this. I need to make sure I'm not training through anything, even mild. And so now I get the gift of your wisdom all the time, and it's great. Well, I could see your training log and there was a moment |
| 1:45.5 | last Friday where we got some health news that wasn't as good as some of the recent health news. We don't need to get into it. Actually, I do need to read the response. Oh, really? You have it up there. Well, I have my training log. This is how much I love going back and forth with you. I have it saved as a bookmark on my computer. Oh my gosh. And what you wrote actually on that was so beautiful. |
| 2:03.5 | I read it this morning and I was like, there is some David wisdom. Okay. Cool. So this gets, I, Friday, I found out I have some cardiac antibodies. Basically, my body is attacking my heart, which honestly isn't that shocking. It's been five years. And I'm like, no shit, Sherlock. It's been five years where I've told you that almost every month. And we've talked about it in the podcast of a ton. Yet you don't believe it until someone with a medical degree comes and gives you a test result. I need something quantitative. What is wrong with me? That's okay. I get it. You're brilliant. It's been five years. And I'm like, oh, that makes so much more sense. Why do you need someone in a lab coat when you can have me with vibes? And like the worst wardrobe you've ever seen. That should work. I basically ignored this when you've told this to me for the last five years. And now I'm like, oh, okay. But I actually have a lot more grace and compassion for myself too at the same time. And it is helpful, I think, for like fully processing this whole situation. But this is |
| 2:51.1 | what you wrote. And this is beautiful. You may have antibodies, but you also have a pro body. Like matter and antimatter, they cancel each other out. And now you're a neutral body. And like matter and antimatter, if there's just one out of a trillion offset between pro body and antibody, then that forms everything in the universe. I'm thinking about you running that this morning. |
| 3:24.9 | Before, it was like 455 a.m. when I got this update. And I was like, damn, bro. You know what? I always tie it back to dad facts about the universe. I'm like, you can take these cardiac antibodies and turn them into matter in the universe. Look at you. So for everybody that doesn't watch as many random YouTube videos as I do, This is all about matter and anti-matter. |
| 3:24.4 | So the fact that the universe exists at all, Everybody that doesn't watch as many random YouTube videos as I do, this is all about matter and anti-matter. |
| 5:21.5 | So the fact that the universe exists at all is pretty shocking because matter and antimatter are usually created an equal pair. They cancel each other out. But at the very start of the universe, the theory is that there was a very small offset, like one in a trillion. I'm not sure the exact number. And that's enough. that amount of matter was enough to form everything we see in the sky. So Megan, that's you. That's you. You've just got just a little bit more of that pro body. As I know right now, because you're wearing booty shorts and a John G. Braw you look really, really good. So what do you think about that? Thanks for being pro-body to neutralize my antibodies. That's true love in this household. We have the best episode for you today. Megan's going to get back to our outline. A quick roadmap. We're going to start with some breaking news on heat training. Then a weird study on red blood cell increases based on sleeping posture. This one is wild. And I was kind of dreading the science because I was like, David's going to have a sleeping at 20 degrees after reading this. But you actually were kind of already sleeping up on an angle. Perhaps even the ideal angle. And I was like, leave it to David, you would optimize that. I feel like he optimized it accidentally. I think we did. Makes me very excited. Then a trial on gene editing for cholesterol levels that could have incredible implications for the entire world of health. In fact, I took this out of the podcast outline this morning because we just had so much science. I was like, I don't know if we can actually do this all. And I'm pretty sure it was the single relationship moment that gave you the ick. You came over to me at 20 minutes after we had a little bit of a disagreement, got down on one knee and said, we can do the crisper. Actually, I said, will you crisper me? Will you crisper me? Which is much more poetic. Come on, man. Then a funny science debate on fatigue resistance terminology from the literature. Glucose and fructose combination science, possibly a low energy availability study and a collagen study, though, I think it might be too much science. Those ones were good. Those were the ones I was fighting for. Yeah, not me, though. I want that crisper. And then finally, a Q&A on car heat. Lots of follow-ups from last week's clean to sport discussion, marathons versus ultra training, and lots more. So much good science. I had a moment this morning. It was 5 a.m. I was reviewing the science. |
| 5:22.9 | I was like, I just love this. |
| 5:37.1 | Like, it's really cool that this is our job to do deep dives on science and make jokes about it. There was actually a friends reference in one of the science papers. And I was like, no way. Wait, to the show friends. To the show friends. You read these studies so deep. |
| 5:39.4 | This was also a letter to the editor, too. So I was really going deep. It was not just the paper. It was the letter to the editor. Okay, I'm already |
| 5:44.8 | giddy about that discussion. But before that, a quick promo for The Feed. Go to TheFeed.com |
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| 6:22.6 | It's a good principle of life is just get expensive things sometimes so you value them. Oh, you got to go full investment |
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