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The After On Podcast

31: Expanding DNA's Alphabet (by half!) | Floyd Romesberg

The After On Podcast

Rob Reid

Science, Technology

4.92.1K Ratings

🗓️ 26 June 2018

⏱️ 81 minutes

🧾️ Download transcript

Summary

Floyd Romesberg added two letters to DNA's ancient four-letter alphabet. He got this running in cells. And coding proteins. His cell lines have passed it down hundreds of generations. Now what?

Transcript

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0:00.0

Welcome to the After-On podcast. I'm your host, Rob Reed.

0:13.6

And this is a series of conversations with thinkers, founders, and scientists.

0:18.1

Take a little time and stretch out because these talks are unhurry and meant to bring you

0:22.8

to a top percentile understanding of something important.

0:27.0

Also, whether you're ready to start up score ideas, a techie or a lit major, take your

0:32.4

time, engage your mind, and you'll be glad you did it.

0:36.5

Especially this week, when we'll be talking to...

0:40.0

Chemist and pioneering DNA Architect Floyd Roomsburg.

0:43.6

For billions of years, all life on Earth, in all of its mad diversity, has been encoded

0:48.8

in the four-letter alphabet of DNA.

0:51.5

ETG and C. That's all it takes.

0:54.8

Bacteria, wasps, polar bears, ragweed, octopuses, palm trees, four letters is all it takes

1:02.2

to enable the full range of life we share our planet with.

1:06.3

Those four letters are all it takes to transmit the blueprints of beings and species across

1:10.2

generations.

1:11.5

And they're all it takes to create the instruction manuals for each of the billions of chemical

1:15.9

reactions that occur in each of your cells, your trillions of cells every minute.

1:21.6

This was true for the dinosaurs.

1:23.4

It was true for the earliest bacterium.

1:25.8

It was indeed true for every critterware aware of, clear back to the common ancestor of

1:30.6

all earthly life.

1:32.7

All beings operated from that four-letter alphabet until just a few years ago, when Floyd

...

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