#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 26 November 2018

⏱️ 168 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.

We discuss:

How Tom got interested in cancer research [9:00];
Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
Otto Warburg and the Warburg effect [30:45];
Germline mutations, somatic mutations, and no mutations [42:00];
Mitochondrial substrate level phosphorylation: Warburg’s missing link [51:30];
What is the structural defect in the mitochondria in cancer? [1:02:00];
Peter’s near-death experience with the insulin suppression test while in ketosis [1:06:30];
Insulin potentiation therapy and glutamine inhibition [1:13:15];
The macrophage fusion-hybrid theory of metastasis [1:39:30];
How are cancer cells growth dysregulated without a mutation? [1:47:00];
What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
Case studies of GBM survivors [2:32:45]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions along the way. I've spent the last several years working
0:19.6	with some of the most successful top performing individuals in the world, and this podcast
0:23.8	is my attempt to synthesize what I've learned along the way to help you live a higher quality
0:28.3	and more fulfilling life. If you enjoy this podcast, you can find more information on today's
0:32.4	episode and other topics at peteratiamd.com.
0:41.9	Hello everyone, welcome to this week's episode of the Peter Atia Drive. My guest this week
0:47.2	is Professor Tom Seafried, who many of you will know, but I suspect an equal number of
0:52.2	you will not know. Tom has come to us through many channels, meaning the requests to speak
0:59.2	with Tom have come on many levels. There's been a lot of requests through social media,
1:04.9	through the site, and of course, based on our discussions with Dom DeGastino. Tom has
1:10.5	been front of mind for quite a while. This is my first time meeting Tom, but I feel sort
1:15.4	of like I know him because I've read so much of his work. Bob Kaplan, who of course you
1:21.0	all know as my trusty right hand guy, who lives in Boston, actually takes a course from Tom,
1:27.8	and he's taken a course in the past and continues to just wander around Tom's office and just hang
1:33.5	out with him overall. In some ways, this felt kind of familiar, though it was my first time meeting,
1:38.1	Tom. Tom's background is that he's got a PhD in genetics and biochemistry from the University of
1:42.3	Illinois. He got that in the mid 70s. I had a bunch of other distinctions that I'm not going to
1:46.0	go into because we're going to link to all that stuff. He did his postdoc in the Department of
1:50.2	Neurology at Yale, and it was there that he first became interested in ketones because of their
1:56.5	application in the amelioration of recalcitrant seizures. As we get into in the episode, that led
	...

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