#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 3 December 2018

⏱️ 142 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, Nav Chandel, a professor of medicine and cell and molecular biology at Northwestern University, discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and metformin’s multifaceted effects on human health, among many topics related to well-being.

We discuss:

What got Nav interested in mitochondria [5:00];
Reactive oxygen species (ROS) [16:00];
Antioxidants: helpful or harmful? [20:00];
Mitochondria as signaling organelles [22:00];
Hydrogen peroxide (H2O2) [25:00];
Mitochondrial DNA [28:00];
Mitochondria and aging [45:00];
Metformin [52:45];
Metformin and the gut microbiome [54:00];
Metformin as complex I inhibitor and the importance of the NADH/NAD ratio [1:01:00];
Anticancer benefits of metformin [1:07:45];
Mitochondrial function is necessary for tumorigenesis [1:15:00];
Are somatic mutations the result of mitochondrial dysfunction? [1:31:30];
Vitamins and antioxidants [1:37:00];
Targeting inflammation in disease [1:43:00];
NAD precursors [1:45:45];
MitoQ [1:52:00];
Metabolite toxicity [1:56:30];
Cortisol and healthy aging [2:02:00];
Nav turns the tables and asks Peter how he deals with the “So what should I eat?” question during social encounters [2:09:00]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions along the way. I've spent the last several years working
0:19.6	with some of the most successful top performing individuals in the world, and this podcast
0:23.8	is my attempt to synthesize what I've learned along the way to help you live a higher quality
0:28.3	more fulfilling life. If you enjoy this podcast, you can find more information on today's
0:32.4	episode and other topics at peteratiamd.com.
0:41.7	Hi everybody, welcome to today's episode of the drive. My guest today is my good friend,
0:47.0	Navdeep, or Nav, as we like to call him, Chendelle. Nav is a professor of medicine and cell and
0:54.5	molecular biology at Northwestern in Chicago, which is where I actually met him to do this interview.
0:59.4	Some of you may recall that name because Nav is one of the cast of characters that I went to
1:05.9	Easter Island with in the fall of 2016, the other being David Sabatini and Tim Ferris. We actually
1:12.6	spoke about this stuff at length on a podcast that Tim recorded while we were on Easter Island.
1:16.9	Nav's real area of expertise is in the mitochondria and in metabolism. In fact, he wrote a book called
1:23.7	Navigating Metabolism, no pun intended in 2015, which I highly recommend for anybody, especially
1:30.8	people who, A, want to understand this stuff and B, don't want to have to buy 17 textbooks and
1:36.2	get into every unearthly detail. In fact, this book was written more for a general audience than a
1:42.7	very specific audience, and I have a copy of it and love it. In this episode, we talk about a
1:47.6	bunch of stuff, but we talk about what got Nav interested in the mitochondria. We get into
1:52.2	Ross or reactive oxygen species, something that I think many of you will have heard of.
1:56.9	And then we talk about some really nuanced stuff, like this stuff about mitochondria being
2:00.9	actual signaling organelles and Ross maybe being beneficial for that signaling. In other words,
	...

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