257. The neuroscience of ketamine and it's effects on depression
Do You F*cking Mind?
Alexis Fernandez-Preiksa - Neuroscientist and Mindset Coach
4.9 • 914 Ratings
🗓️ 2 November 2023
⏱️ 41 minutes
🧾️ Download transcript
Summary
Why is Ketamine being used to treat depression and anhedonia? In this science-y episode I'm going through the neuroscience of Ketamine and the brain, the chemical makeup of the drug, and why it's being used in many trials to treat people with treatment resistant depression and anhedonia.
BRAIN FACT:
ECT therapy – what is It, how does it work, what type of mental disorders is it used as a treatment for. Read more about ECT from the Mayo Clinic https://mayocl.in/3sfPN9W .
EXTRA READING
- Read Understanding Anhedonia https://bit.ly/anhedonia-explained .
- Mandal S, Sinha VK, Goyal N. Efficacy of ketamine therapy in the treatment of depression. Indian J Psychiatry. 2019 Sep-Oct;61(5):480-485. doi: 10.4103/psychiatry.IndianJPsychiatry_484_18. PMID: 31579184; PMCID: PMC6767816.
LISTENER QUESTION:rr
I’m doing my PHD and have realised I don’t think I want a career in the thing I’m studying. After listening to your episode on the Sunk Cost Fallacy (https://bit.ly/46TyOJs ) I’m looking for advice on whether or not I should finish the PHD or not.
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CREDITS
Host: Alexis Fernandez
Executive Producer & Editor: Elise Cooper
Digital Producer: Zoe Panaretos
DYFM Social Producer: Shania Magua
Managing Producer: Sam Cavanagh
See omnystudio.com/listener for privacy information.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | A Listener Production |
| 0:03.9 | Please leave your message after the tone |
| 0:07.4 | Why am I jealous of my ex? |
| 0:09.8 | I am so stressed all the time. |
| 0:11.9 | How do I get into a routine? |
| 0:13.4 | Is TikTok making me anxious? |
| 0:15.2 | I think I'm being manipulated. |
| 0:17.0 | Someone told me you could live with half a brain. |
| 0:19.5 | This is Do You Fucking Mind, Mindset Hacks for a Badass Life, hosted by me, Alexis Fernandez. |
| 0:25.9 | Hello, my beautiful brain-loving beans. |
| 0:29.6 | Welcome to today's episode. |
| 0:30.9 | So this episode is going to be brain-heavy, neuroscience-heavy. |
| 0:34.8 | So for those of you that love that shit, welcome. |
| 0:40.5 | It's also really talking about depression and different aspects of depression and different treatments for depression. I am, as you've |
| 0:45.2 | seen in the title, going to be focusing heavily on ketamine as a treatment for depression and |
| 0:50.9 | anadonia, which I'll go into in a second. But you'll get a really good insight |
| 0:56.1 | as to kind of the quote unquote traditional antidepressants and how they work versus something |
| 1:00.7 | like ketamine, which is kind of up and coming. Well, it's been around for a while, actually, |
| 1:04.4 | but it's more up and coming as a mainstream treatment for depression in certain countries. |
| 1:10.0 | And then I've got a brain factor as well. So if you love |
| 1:12.2 | all the sciencey brain stuff, then lucky you. But I have been requested not only to do stuff |
| 1:16.7 | about ketamine and the effects on the brain, but also a lot on depression. So here we are. We've |
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