238. Why Everybody Is Suddenly Using Empagliflozin
The Kris Gethin Podcast
Kris Gethin
4.9 • 598 Ratings
🗓️ 18 December 2025
⏱️ 33 minutes
🧾️ Download transcript
Summary
Jardiance has exploded in the longevity and fat loss world, but most people still have no idea how it actually works. You hear about glucose dumping, ketone shifts, inflammation changes and kidney filtration, but the mechanism is rarely explained in a way that makes sense.
In this episode I break it down with zero nonsense. You will learn how empagliflozin, the compound in Jardiance, blocks SGLT2 in the kidneys, forces glucose into the urine and creates a consistent calorie leak each day. I show you how that impacts fat loss, metabolic flexibility, ketone production, hydration and long term cardiometabolic health. I also compare Jardiance to retatrutide, GLP-1s, tesamorelin, metformin and tesofensine so you understand which tools target appetite, which target the liver, which target the kidneys and which have the biggest impact on body composition and longevity.
If you want a clear breakdown of where Jardiance actually fits in a real protocol, this episode gives it to you straight.
What's Discussed:
(00:02) Why Jardiance Is Suddenly a Longevity Tool
(05:48) How Jardiance Forces Glucose Out Through the Kidneys
(08:26) The Truth About Fat Loss Results on Jardiance
(12:00) GLP-1s vs Retatrutide vs Jardiance
(17:16) Jardiance vs Metformin for Metabolic Health
(21:05) Tessofensine, Peptides and Where Jardiance Fits
Find more from Kris:
Website: https://www.krisgethin.com/
Instagram: @krisgethin
Youtube: https://www.youtube.com/krisgethin
2 Shred: https://www.unmatchedsupps.com/products/2shred
Thank you to our sponsors:
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LVLUP → If you want to support your gut, tighten up your recovery, and keep your metabolism firing clean, grab TOTAL RECOMP from LVLUP Health. Use code GETHIN for 20% off at lvluphealth.com
Products & Compounds Mentioned in This Episode
Prescription Medications
Jardiance (empagliflozin / SGLT2 inhibitor)
Metformin
Peptides & Related Compounds
Tesamorelin
Ipamorelin
CJC (often paired with ipamorelin)
Tesofensin
Reditudite / Retatutide
GLP-1 Agonists Mentioned
Semaglutide / Ozempic
Other Tools / Supplements Referenced
GDA (general glucose disposal agents)
ElectroShred (electrolytes): https://www.unmatchedsupps.com (Code: KGC10)
Carbohydrates from Vitargo
Transcript
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| 0:00.0 | Welcome to the Chris Getten podcast where we dive deep into the science of building a stronger physique, |
| 0:11.9 | unlocking the secrets of anti-aging and optimizing your health through cutting edge biohacks, |
| 0:17.6 | fitness strategies and mental resilience. I've been a personal trainer for nearly 30 years now and voted the number one transformation |
| 0:25.2 | trainer by governing bodies such as PT Academy, bodybuilding.com and trainerize. |
| 0:31.9 | I am the co-founder of unmatched supplements, co-founder of the Chris Kathleenethyn Jims franchise, and co-founder of my |
| 0:39.6 | online coaching platform, Chris Kethin Coaching, and author of several books. I'm a hybrid athlete, |
| 0:46.2 | a natural pro bodybuilder, and I've competed in events such as Iron Man Triathlon, Ultramarathon, |
| 0:52.0 | Spartan, and many more. My goal with this podcast is to cut through |
| 0:56.7 | the noise of fitness myth, misconceptions, and deliver clear protocols, actual tips, and real |
| 1:04.1 | resilience and science to help you optimize your physique, elevate your physical and mental |
| 1:10.4 | health span, and, of course, enhance your |
| 1:13.5 | life. Hello, everybody. It is Chris Gethen here, and welcome to another episode of the Chris |
| 1:20.8 | Gethen podcast. So today, we're going to center this talk around longevity and fat loss. |
| 1:27.2 | You know, we're going to take a deep dive on a topic that sits right at the intersection, basically, |
| 1:33.2 | of performance, longevity, and metabolic health. |
| 1:36.6 | And the one thing that has fascinated me over the past year or so is something called Jardians. |
| 1:42.3 | If you're watching a video, you can actually see I'm |
| 1:44.3 | holding a box here. It's also known as Impag-Lafrozen Jardians. I like to refer to it for obvious |
| 1:53.2 | reasons. So you may have heard me talk about peptides, GLP-1 agonis, mitochondrial support, |
| 1:58.4 | fat loss strategies. But today I want to go granular on this drug |
| 2:02.8 | that was never really designed as a fat burner, yet as being used in that context. But Jardians |
| 2:08.8 | is really, really for longevity. You know, the more and more people, even though it was created |
... |
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