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The Kris Gethin Podcast

229. The New GLP-1 Pill That Could Replace Injections

The Kris Gethin Podcast

Kris Gethin

Nutrition, Health & Fitness, Fitness

4.9598 Ratings

🗓️ 16 October 2025

⏱️ 27 minutes

🧾️ Download transcript

Summary

GLP-1s have dominated the headlines, but the next wave of compounds is already here, and they're changing the conversation on fat loss, performance, and longevity. In this episode, I break down the science behind four emerging therapies and why you need to know about them now.

We cover how Afoglipron, the first oral non-peptide GLP-1, removes the barrier of injections while delivering results on par with semaglutide. You'll hear why Teriparatide, originally used for osteoporosis, may reduce visceral fat and protect bone density at the same time. I also dive into Mazdutide, a dual GLP-1/glucagon agonist that suppresses appetite while boosting energy expenditure, and Tesofensine, a brain-targeting appetite suppressant with powerful effects on cravings.

I share what the latest clinical data shows, the benefits and risks for both general populations and athletes, and how these compounds could fit into the bigger picture of training, nutrition, and longevity.

This is a must-listen.

What's Discussed:

00:05 — Why GLP-1s have exploded and what's next beyond semaglutide

01:53 — Afoglipron: The first oral GLP-1 and why it's a game changer

07:16 — Teriparatide: Surprising fat loss potential in a bone health drug

10:29 — Mazdutide: The "eat less, burn more" dual agonist

13:17 — Tesofensine: Targeting food noise and cravings in the brain

16:20 — Are these drugs the future of fat loss, or a Pandora's box?


Thank you to our sponsors:  

NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris 

BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/ 

Timeline: My friends at Timeline are offering 20% off, just for my listeners. Head to timeline.com/GETHIN to get started.

LVLUP: Head over to LVLUPHealth.com and use code GETHIN at checkout to get 15% off.

 

Find more from Kris:

Website: https://www.krisgethin.com/  

Instagram: @krisgethin 

Youtube: https://www.youtube.com/krisgethin
Unmatched Supplements: https://www.unmatchedsupps.com/

 

Transcript

Click on a timestamp to play from that location

0:00.0

Now, before we dive into today's episode, I first want to thank our sponsor, Level Up Health.

0:05.7

Now, if you're doing everything right, like you're training hard, you're tracking macros,

0:09.8

you're eating clean, but your fat loss has completely stalled, the issue might not be your metabolism,

0:16.2

nutrition or training plan. It could be in your guts. Now, here's a truth. When you gut lining is inflamed or

0:22.1

damage, your body cannot absorb nutrients efficiently or eliminate toxins properly. This leads to

0:29.4

chronic inflammation, hormonal balance, and stubborn fat that refuses to budge, no matter how dialed

0:36.2

in your program is. And that's why I use ultimate GI

0:40.3

repair from level up health. Now, this cut in edge formula is an orally bioavailable peptide stack

0:47.9

that delivers clinically backed ingredients to heal and protect your digestive system. You've got BPC-157 and GHKCU, peptides that accelerate

0:58.9

gut lining repair. Then you have Larazzoid, which is a peptide, that seals a leaky gut barrier.

1:08.2

Then you've got tributrin, you have zinc al-canocene, which are compounds that reduce

1:14.4

inflammation and strengthen digestion. Then you have cursetin and sodium bicarbonate, which are

1:19.5

ingredients to support gut integrity and enhance absorption. And yes, all of these are found in

1:26.1

Level Up Health's ultimate GIair, which is probably the most

1:30.9

powerful gastrointestinal healing product in the world.

1:36.5

Because here's a deal.

1:38.0

Sluggish digestion equals sluggish metabolism.

1:42.0

That's a fact.

1:43.3

When your gut isn't optimized, your energy recovery,

1:45.9

your fat burning potential are all compromised. You fix your gut and everything else starts working

1:51.6

again. And Level Up makes it extremely simple and convenient to heal it fast. So head on over

1:57.7

to levelupehealth.com and use the code gethin at checkout for 15% off your order sitewide.

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