227. GLP Q&A: Can You Lose Fat and Keep Muscle on GLP agonists?

The Kris Gethin Podcast

Kris Gethin

Fitness, Health & Fitness, Nutrition

4.9 • 598 Ratings

🗓️ 2 October 2025

⏱️ 19 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Most people using GLP agonists are doing it wrong. Semaglutide? Tirzepatide?
They're not magic pills, they're misunderstood tools. In this episode, I answer your most common questions and break down what these drugs actually do inside the body.

We get into the real science: how GLPs suppress appetite, slow digestion, improve insulin sensitivity, and change energy balance. I explain the difference between GLP‑1, dual agonists like tirzepatide (GLP + GIP), and next-gen options like retatrutide (GLP + GIP + glucagon).

You'll learn why fat loss happens, why muscle loss is a major risk, and how to train, eat, and supplement so you stay jacked, not soft. We cover the rebound effect when you stop, what stacks are worth considering, and how to avoid wrecking your gut or your gains in the process.

If you're serious about fat loss, muscle retention, and metabolic health, this is mandatory listening. These compounds can change your trajectory. Or wreck it. The difference is your discipline.

What's Discussed:

(00:01) Are GLP Drugs Just Fancy Appetite Suppressants?
(02:57) The Real Reason You're Losing Muscle on Semaglutide
(05:23) What Happens When You Come Off? The Rebound Most Miss
(06:59) Using GLPs as an Athlete? Here's What Can Go Sideways
(13:06) How to Actually Maximize GLPs Without Wrecking Your Gains

Thank you to our sponsors:

NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris
BiOptimizers - code KRIS10 for 10% off https://bioptimizers.com/

Find more from Kris:

Website: https://www.krisgethin.com/

Instagram: @krisgethin

Youtube: https://www.youtube.com/krisgethin

Unmatched Supplements: https://www.unmatchedsupps.com/

Transcript

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0:00.0	Welcome to the Chris Getten podcast where we dive deep into the science of building a stronger physique,
0:11.9	unlocking the secrets of anti-aging and optimizing your health through cutting edge biohacks,
0:17.6	fitness strategies and mental resilience. I've been a personal trainer for nearly 30 years now and voted the number one transformation
0:25.2	trainer by governing bodies such as PT Academy, bodybuilding.com and trainerize.
0:31.9	I am the co-founder of unmatched supplements, co-founder of the Chris Kathleenethyn Jims franchise, and co-founder of my
0:39.6	online coaching platform, Chris Kethin Coaching, and author of several books. I'm a hybrid athlete,
0:46.2	a natural pro bodybuilder, and I've competed in events such as Iron Man Triathlon, Ultramarathon,
0:52.0	Spartan, and many more. My goal with this podcast is to cut through
0:56.7	the noise of fitness myth, misconceptions, and deliver clear protocols, actual tips, and real
1:04.1	resilience and science to help you optimize your physique, elevate your physical and mental
1:10.4	health span, and, of course, enhance
1:13.2	your life.
1:15.6	Hello, everybody.
1:16.8	Chris Gethyn here and welcome back to another episode of the Chris Geffen podcast.
1:20.8	Now, today, we are doing something different because I have been inundated with so many
1:26.6	questions as of recent in regards to GLP1s,
1:30.8	GLP 2s, GLP 3s.
1:33.0	So I'm going to be answering your most common questions about GLP receptor agonis.
1:39.5	So you've got like your semi-glutide, you're Cispetide, and you're redid glutide.
1:43.3	So usually referred to in
1:45.2	the research circles as GLP-1s, twos, and threes. And these are definitely the most talked about
1:51.3	compounds or peptides in health, fitness, longevity right now. And there's a lot of confusion
	...

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