#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
Lex Fridman Podcast
Lex Fridman
4.7 • 13.6K Ratings
🗓️ 7 June 2021
⏱️ 110 minutes
🧾️ Download transcript
Summary
David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
David’s Twitter: https://twitter.com/davidasinclair
David’s Website: https://lifespanbook.com
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OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(09:34) – Staying young at heart
(13:31) – Bringing people back to life
(19:05) – Wearables and tracking health data
(28:18) – How to solve aging
(38:23) – Why do we age?
(43:50) – Genetic reset switch that reverses aging
(46:20) – AI in biology
(48:52) – Health data
(56:58) – Fasting
(1:04:29) – Diet
(1:12:41) – Exercise
(1:18:01) – Sleep
(1:26:29) – Data
(1:32:00) – Extending lifespan
(1:34:42) – Immortality
(1:40:28) – Denial of death
(1:43:45) – Meaning of life without death
Transcript
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| 0:00.0 | The following is a conversation with Davidson Claire. |
| 0:02.7 | He's a professor in the Department of Genetics at Harvard |
| 0:06.2 | and co-director of the Paul F. Glenn Center for the Biology of Aging |
| 0:10.6 | at Harvard Medical School. |
| 0:12.2 | He's the author of the book, Life Span and Co-Founder of several biotech companies. |
| 0:17.0 | He works on turning age into an engineering problem and solving it, |
| 0:22.1 | driven by a vision of a world where billions of people can live much longer |
| 0:25.9 | and much healthier lives. |
| 0:28.1 | Quick mention of our sponsors. |
| 0:30.4 | On it, clear, national instruments, and I, simply safe and lean out. |
| 0:36.8 | Check them out in the description to support this podcast. |
| 0:40.0 | As a side note, let me say that longevity research challenges us to think |
| 0:44.1 | how science and engineering will change society. |
| 0:47.6 | Imagine if you can live 100,000 years, even under control conditions, |
| 0:51.9 | like in a spaceship, say, then suddenly a trip to office entari |
| 0:55.9 | that is 4.37 light years away takes a single human lifespan. |
| 1:01.2 | And on the psychological, maybe even philosophical level, |
| 1:05.1 | as the horizons of death drift farther into the distance, |
| 1:08.7 | how will our search for meaning change? |
| 1:11.1 | Does meaning require death or does it merely require struggle? |
| 1:15.6 | Reprogramming our biology will require us to delve deeper |
| 1:19.4 | into understanding the human mind and the robot mind. |
... |
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