GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/ageproofbrain 2:35 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:45 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:05 - AVALONX SUPPLEMENTS: ​AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens, Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 6:05 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:45 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts Text "BEAUTYCOUNTER" To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 11:30 - Marc's Background 13:30 - Insulin Degrading Enzyme 14:50 - The Relationship Between Insulin Levels And Brain Health 16:05 - The Problem With 2 New Alzheimer's Medications  18:30 - Defining The Brain Plaques And The Relation To Cognitive Decline 20:30 - Can You Have Cognitive Decline Without Brain Waste? 21:40 - Diagnosing Brain Waste 22:40 - How To Get Rid Of Brian Waste 26:10 - The Glymphatic System 28:00 - How Is The Waste Removed 29:00 - What Is The Role Of Brain Fluid? 30:10 - Is There A Relation To Intelligence? 31:15 - The Size Of Our Brain And How It Changes 34:45 - What Is Active Learning? 36:15 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 42:00 - Is Pruning More Genetic Or Environmental 43:25 - How Much Influence Do Parental Rearing Have On Brain Development? 47:30 - How We Crystalize Memories By Revisiting Them 48:15 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 51:00 - Why Is APOE Connected To Cognitive Decline? 52:50 - Why Did APOE Develop? 53:40 - APOE Risk Factors 55:15 - Memory Formation  58:55 - Short Term Memory 59:30 - Working Memory 1:01:00 - Can We Lose Memories? 1:02:40 - Is Scent The Strongest Recall Of Memory? 1:04:15 - HOLDON BAGS: Reduce Single-Use Plastic! HoldOn Makes Heavy Duty, Plant-Based, Nontoxic And 100% Home Compostable Trash, Bags, Sandwich Bags, And Gallon Bags To Help Combat Our Toxic Plastic Environment! Sustainability Has Never Been More Simple! Visit Holdonbags.Com/Melanieavalon And Enter Code MELANIEAVALON At Checkout To Save 20% Off Your Order! 1:07:45 - Distractions And Focus Shift 1:10:15 - The Connection Between Vision Loss Or Hearing Loss And Dementia 1:12:05 - What About Being Born Blind Or Deaf 1:12:50 - Ways To Learn And Ways To Innovate 1:16:45 - The Diet For Brain Health