4.8 • 1K Ratings
🗓️ 16 April 2025
⏱️ 32 minutes
🧾️ Download transcript
How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables, and then to the PURPOSE trials, which look at the use of long-acting lenacapavir as PrEP — a potential game-changer in the field of HIV.
Listen to this latest episode of Beyond Journal Club, a collaboration between CoreIM and NEJM Group, where we put research into context, telling the story of how we arrived at the current standard of care, appreciating the clinical question of the trial at hand, and interpreting what the findings may mean for these patients.
🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply!
Timestamps:
(02:25) | HIV PrEP Daily Truvada and Descovy
(07:48) | On-Demand Prep
(13:25) | Purpose Trials
(20:56) | Discussion of Effectiveness to Efficacy
Tags: CoreIM, Internal Medicine, Primary Care, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student, HIV Prevention, Infectious Disease
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0:00.0 | I am so excited to have Newland Journal of Medicine's editorial fellowship program as a sponsor for this podcast. |
0:06.8 | Here is Dr. Harleen Marwa, a current fellow on her experience. |
0:10.7 | Some of the things that we expected were to really strengthen our muscles. |
0:14.7 | I'm going to interpret scientific literature, get this amazing experience of sitting in on these editorial meetings twice |
0:21.1 | a week where they decide which papers to publish and why. |
0:25.5 | And being part of those conversations has been really fascinated. |
0:29.3 | I think for me, some of the surprising things has been learning a lot of lessons in |
0:33.5 | leadership. |
0:34.2 | And so how do you facilitate navigating those conversations? |
0:38.8 | How do you approach scientific debate? And while thinking really critically about scientific integrity and research, |
0:48.7 | I think that has been just such a useful lesson and experience began out of the year. |
0:55.7 | And then to be supported by the work culture at the New England Journal of Medicine, |
1:01.1 | all the deputy editors here and associate editors and staff are so approachable. |
1:07.1 | There's also all these informal learning experiences, like just watching how they lead |
1:11.1 | conversations in hearing the kinds of questions they ask. |
1:14.7 | And yes, this is a one-year full-time paid editorial fellowship. |
1:18.8 | Check out the show notes for the link to learn more about the program and application. |
1:22.8 | And with that, let's get into the episode. |
1:24.5 | Welcome to Beyond Journal Club, a collaboration between Core I.M. and EJM Group. |
1:29.1 | The goal of Beyond Journal Club is to take landmark clinical trials to put them into context, |
1:33.6 | telling us a story of how we got to where we are and what it means for how we take care of patients. |
1:38.4 | I'm Dr. Greg Katz, cardiologist at NYU. |
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