#150 - Dom D’Agostino: Ketogenic Diets, Exogenous Ketones, Measuring Ketosis, Long-Term Keto, Fasting & Caloric Restriction, Metabolic Flexibility, The Dawn Effect, And More!

The Melanie Avalon Biohacking Podcast

Melanie Avalon

Alternative Health, Nutrition, Health & Fitness

4.5 • 650 Ratings

🗓️ 17 June 2022

⏱️ 133 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/domdagostino 2:25 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:40 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 10:30 - NASA's NEMO 12:50 - The Aquarius Habitat And Hyperbaric Effect 17:55 - Performance Ketogenic Diet 19:15 - CNS Oxygen Toxicity 21:25 - Dom's Research Into The Ketogenic Diet 23:45 - Anti Seizure Drugs Vs Keto 26:30 - What Makes Keto Beneficial? 28:50 - Seizure Control With Other Low Carb Diets 31:00 - Root Cause In Seizure 34:00 - The Spectrum Of Ketosis 35:30 - Becoming Fat Adapted 37:20 - Higher Resting Blood Glucose On Keto 38:00 - The Dawn Effect 41:50 - Cryotherapy, Ketones, And Blood Glucose 45:00 - Why Do We Enter Ketosis? 48:30 - Acetyl CoA 50:20 - Starvation And Metabolic Disorders That Prevent Ketosis 55:10 - The Inuit 56:30 - Long Term Ketosis 58:40 - Is Chronic Ketosis Healthy? 1:00:25 - Fat Adaptation Through Restricted Carbs Vs Restricted Dietary Fat 1:04:40 - Ketones And Mitochondrial Uncoupling 1:12:30 - Lactate 1:15:20 - Ketones To Fuel The Brain 1:18:00 - Strict Keto With Carb Cycling Vs Moderate Carb Keto 1:24:15 - Ketone Bodies And Measuring Ketosis 1:30:30 - Acetone On The Breath 1:34:10 - Acetone For Anti Seizure Effects 1:35:50 - Personalizing The Ketogenic Diet For Our Genetics 1:38:15 - Exogenous Ketones Vs Endogenous Ketones 1:40:40 - Salts Vs Esters 1:44:10 - Can We Become 'Ketone Resistant'? 1:45:55 - Chasing Ketones 1:47:45 - 'Metabolic Memory' 1:51:00 - Is Keto Pro-Cancer Or Anti-Cancer? 1:55:00 - Pairing Keto With Cancer Treatments

Transcript

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0:00.0	I embarked on this idea of developing a ketogenic diet in a drug, which led me to develop
0:05.8	ketone esters and ketone salts. The ketogenic diet is the only therapy that we know of, that
0:10.8	you can follow it for a period of time. It may be repairing and rewiring the brain and balancing
0:17.8	brain neurochemistry and metabolism. We don't know if reducing fluctuations in glucose in non-diabetic people
0:26.3	will have long-lasting benefit, but you get a hunch that it will.
0:31.6	Welcome to the Melanie Avalon Biohacking Podcast, where we meet the world's top experts to explore the secrets of health,
0:40.2	mindset, longevity, and so much more. Are you ready to take charge of your existence and biohack
0:47.1	your life? This show is for you. Please keep in mind, we're not dispensing medical advice
0:52.9	and are not responsible for any outcomes
0:55.2	you may experience from implementing the tactics lying herein. Are you ready? Let's do this.
1:03.7	Welcome back to the Melanie Avalon biohacking podcast. Oh my goodness, friends, I am so honored,
1:10.3	so excited about today's episode.
1:12.2	The concept of ketones, the ketogenic diet, ketosis. Obviously, that is a topic that I am thinking
1:19.5	about all the time, especially with the Intermittent fasting podcast and with all of the work
1:24.9	that I've done on this show. And who is the go-to authoritative
1:29.6	figure on ketones but Dom Diagostino? It was honestly thrilling to bring him on the show.
1:37.4	And on top of that, he is just one of the nicest, kindest human beings. I don't know if we
1:42.5	talk about this in the episode, but we actually had to
1:45.5	troubleshoot for about an hour prior to recording because the connection wasn't working with his
1:51.4	computer. So not only did he put up with that for an hour, but then he still continued to talk
1:57.3	with me for almost two hours on all of these topics. I so enjoyed it. I got to finally
2:03.0	ask all of those nitty, gritty, granular questions I have about ketones. I think you guys are
	...

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