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The Peter Attia Drive

#120 - AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.77.3K Ratings

🗓️ 20 July 2020

⏱️ 28 minutes

🧾️ Download transcript

Summary

In part 2 of this special AMA episode, ketosis expert Dom D’Agostino once again joins Bob Kaplan, Peter’s Head of Research, to discuss the impact of ketosis on various chronic diseases as well as the latest research on the metabolic management of cancer. Dom also discusses the numerous applications of hyperbaric oxygen therapy, provides insights into the application of ketosis on female health and performance, and much more. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page.

We discuss:

  • Update on Dom’s Press-pulse therapeutic strategy for the metabolic management of cancer [2:05];
  • Potential role for vitamin C in cancer treatment [12:45];
  • Glutamine targeting in cancer therapy—evidence that the mitochondria in cancer are damaged? [17:45];
  • Can a ketogenic diet lessen the toxicity of cancer therapies? [24:45];
  • 3BP—a promising agent in cancer therapy [26:45];
  • The relationship between cancer and ketogenic diets [29:30];
  • Hyperbaric oxygen therapy (HBOT)—primer, protocols, and therapeutic uses [33:30];
  • Is there a potential role for HBOT in treating COVID-19 patients? [44:15];
  • Non-cancer applications of HBOT [47:30];
  • The inverse relationship between glucose and ketones [50:30];
  • Is a ketogenic diet appropriate for type 1 diabetics? [54:00];
  • How ketosis may reduce the risk for Alzheimer’s disease and Parkinson’s disease [1:00:30];
  • Ketosis for females—considerations, fertility, performance, and the latest research [1:11:00];
  • Low-carb diets during pregnancy and postpartum [1:17:00];
  • A high-protein diet to counteract common hormonal issues associated with the ketogenic diet [1:21:15];
  • Nutritional tips for remaining metabolically flexible [1:22:45];
  • What is one belief Dom has changed his mind about? [1:26:45];
  • In utero experiments, and other interesting questions Dom wants to explore [1:29:45];
  • The anti-catabolic effect of ketones, cancer cachexia, and nutritional interventions for cancer patients [1:38:30];
  • What is the one interesting experiment Dom would do if money and time were not a barrier? [1:46:25]; and
  • More.

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Show notes page for this episode: https://peterattiamd.com/domdagostinoama02/

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Transcript

Click on a timestamp to play from that location

0:00.0

Hey everyone, welcome to a sneak peek, ask me anything, or AMA episode of the Drive Podcast.

0:16.5

I'm your host, Peter Atia.

0:18.3

At the end of this short episode, I'll explain how you can access the AMA episodes in full,

0:22.9

along with a ton of other membership benefits we've created.

0:25.9

Before you can learn more now by going to peteratia-md.com forward slash subscribe.

0:31.5

So without further delay, here's today's sneak peek of the Ask Me Anything episode.

0:36.7

Hey everyone, welcome to part two in our AMA series with Dom DeGustino.

0:45.2

As a reminder, you'll note that this interview had been scheduled for a very long time,

0:48.9

and just when it was about to happen, I had to go to Mars on a spaceship that did not

0:54.0

contain a zoom setup, and I was unable to be a part of it, but both Dom and Bob Kaplan

1:00.8

might have researched graciously agreed to do it in my absence.

1:04.5

So you will once again be graced by the presence of Bob and Dom, speaking, instead of having

1:09.6

to listen to me.

1:11.3

In this second episode, Bob and Dom dive deep again.

1:15.0

This time, really focusing on the effects of ketosis on various chronic diseases, Dom's

1:19.6

work with hyperbaric oxygen therapy and its numerous applications.

1:23.5

As long as the applications of ketosis on female health and performance, this is a topic

1:28.6

that I know very little about outside of some reproduction, and also it's something that

1:32.7

many of you have been asking about, and frankly, there's just not enough information out

1:36.1

there on such topics.

1:37.9

Dom is an associate professor at the University of South Florida, where he teaches at the

1:41.4

College of Medicine and in the Department of Molecular Pharmacology, Physiology.

...

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