#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 29 June 2020

⏱️ 104 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness.

We discuss:

His background and early work with coronaviruses [2:45];
The coronavirus family—various types, common traits, and scientific understanding [9:00];
The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45];
Insights from the 2002 SARS outbreak [28:30];
Insights from the 2012 MERS outbreak [35:00];
Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00];
COVID-19 survivor potential for long-term damage [53:30];
Using the current pandemic for lessons on future preparedness [57:00];
Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00];
Prevention and treatment strategies for COVID-19 and future diseases [1:22:30];
Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30];
Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Drive Podcast.
0:13.0	I'm your host, Peter Atia.
0:14.8	This podcast, my website, and my weekly newsletter, all focus on the goal of translating
0:18.7	the science of longevity into something accessible for everyone.
0:22.4	Our goal is to provide the best content in health and wellness, full stop, and we've
0:26.6	assembled a great team of analysts to make this happen.
0:29.4	If you enjoy this podcast, we've created a membership program that brings you far more
0:33.2	in-depth content if you want to take your knowledge of this space to the next level.
0:37.2	At the end of this episode, I'll explain what those benefits are, or if you want to learn
0:41.0	more now, head over to peteratiamd.com forward slash subscribe.
0:46.2	Now, without further delay, here's today's episode.
0:49.0	I guess this week is Stanley Proman.
0:53.2	Stanley is a professor of microbiology and immunology, along with being a professor of
0:57.6	pediatrics and the chair of virology at the University of Iowa.
1:02.6	Stanley has researched coronaviruses for nearly four decades, and his lab is currently using
1:08.5	mouse models for SARS-CoV-1 and SARS-CoV-2 to better understand the more severe diseases
1:15.2	that affect humans.
1:16.2	I wanted to talk with Stanley for a few months now.
1:19.9	Understandably, he has been incredibly busy.
1:22.3	We have been part of a collaboration that is working on a longer study trying to understand
1:27.5	the durability of immune response and the impacts of that, which we discussed very briefly
1:31.5	at the end of this podcast.
	...

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