#074 - Benjamin Bikman, Ph.D.: Insulin Resistance, Human Metabolism, Obesity, Diabetes, Mitochondrial Function, Reproductive Issues, Fasting, And More!

The Melanie Avalon Biohacking Podcast

Melanie Avalon

Alternative Health, Nutrition, Health & Fitness

4.5 • 650 Ratings

🗓️ 31 December 2020

⏱️ 129 minutes

🔗️ Recording | iTunes | RSS

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Summary

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/insulin 1:45 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/PaleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! Go To Melanieavalon.com/nutrisenseCGM And Use Coupon Code MelanieAvalon For 15% Off Select Packages 2:35 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 8:55 - Ben's Personal Story 13:15 - Insulin's Role In Disease 17:05 - Measuring Insulin 17:25 - What Is Insulin? 19:30 - Insulin Signaling 20:40 - Defining Insulin Resistance 21:35 - Insulin Resistance And Sex Hormones 23:35 - Fatty Acid Transportation 25:15 - High Blood Glucose; Low Insulin 25:35 - Gluconeogenesis 27:15 - Homeostasis Between Gluconeogenesis And Insulin 28:00 - Communication And Regulatory Signaling 31:05 - PCOS 33:05 - The Role Of Fat Cells In Insulin Resistance 34:30 - How We Gain Fat 36:55 - Insulin Resistance In Fat Cells 37:40 - Inflammation In Fat Cells 39:30 - Insulin Sensitivity In The Morbidly Obese 41:20 - The Role Of Hypertrophy Vs Hyperplastic Cells 43:35 - Differences In BMI Application 46:55 - Vitamin D, And K2 52:00 - Visceral Fat Vs Subcutaneous Fat 52:55 - Macrophages And Foam Cells 56:40 - Ceramides, "Bad" Fat In The Body 59:05 - Creating Insulin Resistance 59:40 - Inflammation And Ceramides 1:00:25 - Insulin Resistance In Muscle Vs Fat 1:03:40 - Glycogen Storage; Liver Vs Muscles 1:05:40 - Muscle Glycogen Usage 1:07:10 - Liver Glycogen Depletion And Ketosis 1:09:50 - Increased Glycogen Storage 1:12:10 - Water Demands Of Glycogen 1:13:20 - Fat Storage Vs Glucose Storage 1:15:45 - Fruit Diets 1:17:40 - Non-Essential Carbohydrates 1:19:30 - Essential Glucose 1:21:00 - Carbohydrate Conversion To Fat 1:22:55 - Types Of Fat Created By Type Of Carbohydrate 1:24:20 - HFLC Vs LFHC 1:27:20 - How Saturated Fat Impacts Insulin Resistance 1:29:10 - Saturated Fat In The Blood 1:30:30 - Palmitate Production 1:32:00 - Oleic Acid Storage 1:33:10 - Monounsaturated Fat's Protective Effect 1:34:00 - Natural Fats; Animal And Plant Saturated Fats 1:35:15 - Saturated Fat In A Mixed Macro Diet 1:37:10 - Order Of Macro Consumption 1:41:05 - Carb + Protein Plant Sources 1:45:00 - Physiological Insulin Resistance 1:50:00 - Metabolic Inflexibility 1:54:00 - A Practical Diet Including Carbs 1:56:40 - Glycemic Load And Glycemic Index 1:58:10 - CGM Usage 1:58:40 - Berberine, Cinnamon, ACV For Glucose Control

Transcript

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0:00.0	Insulin is a small little, what's called a peptide hormone.
0:04.0	Basically means it's kind of like a little protein.
0:06.0	So there are insulin receptors on every cell.
0:08.0	It will stimulate a cell to store energy.
0:11.0	That's its theme.
0:12.0	Insulin resistance has when two things are happening together.
0:14.0	That is when some cells have stopped responding to insulin properly,
0:19.0	and we have elevated insulin.
0:21.2	I just found that insulin resistance was really significantly contributing to virtually every
0:26.0	chronic disease.
0:27.1	An ideal life is one that is spent not spiking insulin all the time.
0:31.5	Welcome to the Melanie Avalon Biohacking Podcast, where we meet the world's top experts to explore the secrets of health,
0:40.2	mindset, longevity, and so much more. Are you ready to take charge of your existence and biohack
0:47.1	your life? This show is for you. Please keep in mind. We're not dispensing medical advice
0:52.9	and are not responsible for any outcomes you may
0:55.7	experience from implementing the tactics lying herein. Are you ready? Let's do this.
1:04.0	Welcome back to the Melanie Avalon Biohacking Podcast. Friends, I am so excited about this episode. I know it's going to be so popular,
1:13.2	especially given how much we talk about insulin on my other show, the Interminton
1:17.3	Fasting podcast. Now I have this episode to constantly refer listeners to because we cover it
1:22.9	all. We dive deep into all things insulin, blood sugar control, what's going on with that.
1:29.0	I really, really think you guys will enjoy this conversation.
1:32.3	This is one of those episodes where the transcript will definitely come in handy.
	...

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