Welcome to Helix Talk, an educational podcast for healthcare students and providers covering real-life clinical pearls, professional pharmacy topics, and drug therapy discussions.

This podcast is provided by pharmacists and faculty members at Rosal Franklin University College of Pharmacy.

This podcast contains general information for educational purposes only. This is not

professional advice and should not be used in lieu of obtaining advice from a qualified health

care provider. And now on to the show. Welcome to Helix Talk episode 64. I'm your co-host

Dr. King. I'm Dr. Schumann. And I'm Dr. Vettel. And today I'm excited that we're going to be talking about something that I'm really, really passionate about, that's migraine management.

So, the name of this episode with apologies to the band The Cl go through and talk about the history of ergotamine and its clinical use,

something that's really fascinating as it's evolved over time. And they can see it as this important

milestone in terms of what we know, not just about migraine management, but about overall what we

know about our alpha and beta receptor pharmacology. And I think what's kind of cool about the ergots

is kind of how they came about being a

medication to begin with.

You know, sometimes you think of medications that are built in a lab and a chemical synthesis

kind of standpoint, but these actually have a neat history to them.

Yeah, and now, especially now that we don't get to see a whole lot of ergotamine

has medication prescription,

but then again, it's good to know where they came from and what was its use

and what can we do with them still being in the market.

So just to start with first, what in the world is this and what is maybe what is some of the

historical significance?

So what it is, it's a product that was formed from a fungus known as clavisept's pururia,

and it grows on rye plants in particular.

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