#029 Jed Fahey, Sc.D. on Isothiocyanates, the Nrf2 Pathway, Moringa & Sulforaphane Supplementation
FoundMyFitness
Rhonda Patrick, Ph.D.
4.8 • 5.5K Ratings
🗓️ 6 January 2017
⏱️ 152 minutes
🧾️ Download transcript
Summary
Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University.
In this episode, you'll discover:
- (00:00) Introduction
- (03:44) What is sulforaphane?
- (10:25) The NRF2 pathway, a master regulator of antioxidants
- (14:22) Cruciferous vegetables are rich sources of sulforaphane
- (20:39) Does cooking broccoli destroy sulforaphane?
- (26:00) Sulforaphane supplements vary widely in quality
- (36:41) Antibiotics wipe out sulforaphane-producing bacteria in the gut
- (46:44) Managing Helicobacter pylori growth with a sulforaphane-rich diet
- (56:15) Sulforaphane reduces inflammation, but does it extend lifespan?
- (01:11:31) The therapeutic potential of sulforaphane for autism spectrum disorders, Alzheimer's disease, and schizophrenia
- (01:22:44) Research challenges and clinical trials
- (01:30:51) Is sulforaphane an anti-depressant?
- 01:34:50 - Moringin from moringa may be an alternative to sulforaphane with similar bioaction
- (01:53:55) How to maximize sulforaphane conversion
- (02:13:27) Testing the anticancer power of sulforaphane
If you’re interested in learning more, you can read the full show notes here.
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Transcript
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| 0:00.0 | Hello again. In my last podcast, I talked about the effects of a group of compounds known as |
| 0:04.7 | isothiosinates that are produced by the Brasica family of vegetables, including broccoli, |
| 0:09.9 | kale, califlower, and so many others. In the podcast, which actually centered around one |
| 0:14.9 | particularly well-researched isothiosinate known as sulfurophane, was over 45 minutes long. |
| 0:20.9 | I talked about so much in the context of these plants and compounds, including changes in cancer |
| 0:26.0 | risk in humans, reductions in inflammation, causing significant detoxification of air pollutants, |
| 0:31.8 | animal and human studies, and various neurological disorders, such as autism, schizophrenia, |
| 0:36.5 | Alzheimer's disease, traumatic brain injury, and more. I talked about changes in animal models for |
| 0:42.2 | stress-induced depression, talked about heart disease and all-cause mortality and aging in general, |
| 0:47.6 | and also about DNA damage. This is exactly why we're going back in for round two today. This time, |
| 0:54.4 | however, I bring in someone fresh into the discussion, someone that is actually an authority on |
| 0:59.1 | this research. Today's guest is Dr. Jed Fahee, a multi-decade veteran in this field of research and |
| 1:05.5 | director of the Coleman Keema Protection Center at Johns Hopkins. As you'll quickly learn from |
| 1:11.1 | listening to this interview, Dr. Fahee has for many years been at the center, along with his |
| 1:16.6 | colleagues, of a whirlwind of this type of research. There is hardly a topic in which we discuss, |
| 1:22.4 | in which he doesn't have an anecdote about a study he was involved in, or in some cases, |
| 1:27.0 | interesting tribal knowledge that may not even be published, but is nonetheless interesting and |
| 1:31.6 | an important part of the story that is unique to his particular vantage point. His lab and those |
| 1:36.7 | of his colleagues in a way have served as a critical infrastructure for the rest of the research |
| 1:41.9 | community, often helping to facilitate a broad range of studies to get the access they need |
| 1:47.3 | to broccoli extracts and much more. This becomes especially impactful when you realize in 2016 |
| 1:53.7 | alone there were over 150 new studies that were published on this extremely promising |
... |
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