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FoundMyFitness

#013 How The Gut Microbiota Affects Our Health with Dr. Erica & Dr. Justin Sonnenburg

FoundMyFitness

Rhonda Patrick, Ph.D.

Nutrition, Medicine, Health & Fitness

4.8 • 5.8K Ratings

šŸ—“ļø 3 September 2015

ā±ļø 47 minutes

šŸ§¾ļø Download transcript

Summary

Dr. Justin Sonnenburg
Dr. Justin Sonnenburg is an associate professor of microbiology and immunology at Stanford and Dr. Erica Sonnenburg is a senior research scientist in the Sonnenburg lab where they research many aspects the interaction between diet with the 100 trillion or so bacteria in the gut (specifically the colon) and how this impacts the health of the host (which in this case is a laboratory research mouse).

In this episode, we discuss...Ā 

  • (00:00)Ā Introduction
  • (02:50)Ā What is the gut microbiota?
  • (08:10)Ā A lack of dietary fiber starves the gut microbiota
  • (16:13)Ā The close interplay of our gut and immune system
  • (17:58)Ā Connecting the dots between the gut, immune system, inflammation, and autoimmune diseases
  • (20:45)Ā A diet with a variety of fibers promotes microbiome diversity and healthĀ 
  • (25:30)Ā Artificial sweeteners induce glucose intolerance by altering the gut microbiota
  • (29:00)Ā Individualized responses to repeated antibiotic perturbation
  • (30:27)Ā The risks of antibiotic overuse
  • (32:10)Ā Probiotics can support a healthy microbiota following antibiotics
  • (38:05)Ā Factors during birth and infancy that influence microbiome development

If you're interested in learning more, you can read the full show notes here.

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Transcript

Click on a timestamp to play from that location

0:00.0

Hello, my dear podcast listener.

0:02.0

In this episode, I speak with doctors Justin and Erica Stonenberg, who run a lab at Stanford

0:06.4

researching the nuances of 100 trillion or so tiny bacteria that inhabit the gut in numbers

0:11.8

that exceed that of even your own cells, and do much to affect your health.

0:16.6

We discuss the pivotal role fire plays in fueling good bacteria in the gut to produce compounds

0:21.2

that regulate the immune system, including increasing the number of T regulatory cells, which

0:26.4

are specialized types of immune cells that keep the immune system in check and prevent

0:30.7

autoimmune responses, and how these compounds also increase other types of blood cells in

0:35.6

the body in a process known as hematopoesis.

0:38.8

We also talk about how the lack of fiber in the typical American diet actually starves

0:43.5

these good bacteria of their food.

0:45.7

This has an effect not only on the immune system and autoimmune diseases, but also results

0:50.7

in the breakdown of the gut barrier, which leads to widespread inflammation and inflammatory

0:56.2

diseases.

0:57.1

Is some of this sounding familiar?

0:59.1

That's because I also talk a bit about some of this with Dr. Mark Scheginaga in a recent

1:04.0

podcast called Corybar, Micronutrients, Fiber, and Polyphenols in a bar.

1:09.4

So make sure to check that out also on iTunes.

1:13.3

Lastly in this podcast, Dr. Erica Stonenberg talks about how C-sections have a negative effect

1:19.8

on infants' gut due to the lack of exposure to bacteria present in the mother's vaginal

1:25.3

canal and how the use of formula deprives the infant not only of the good bacteria present

1:31.5

in mom's gut, but also from specialized carbohydrates and breast milk that are good

...

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