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FoundMyFitness

#012 Dr. Ronald Krauss on LDL Cholesterol, Particle Size, Heart Disease & Atherogenic Dyslipidemia

FoundMyFitness

Rhonda Patrick, Ph.D.

Nutrition, Health & Fitness, Medicine

4.8 • 5.8K Ratings

šŸ—“ļø 27 August 2015

ā±ļø 84 minutes

šŸ§¾ļø Download transcript

Summary

Dr. Ronald Krauss

Dr. Ronald Krauss, M.D. is the director of atherosclerosis research at Children's Hospital Oakland Research Institute, Adjunct Professor at UCSF and UC Berkeley. Dr. Krauss is really one of the pioneering scientists that changed the way we all think about cholesterol and saturated fat. He developed an assay that allows the quantification of low density lipoprotein particle size and concentration (known to the wider world as LDL cholesterol) based on a technique which determines the size of the particle based on physics...meaning the speed at which it flies through the air.

In this episode, we discuss...

  • (00:00)Ā Introduction
  • (03:58)Ā An overview of lipoproteins – HDL, LDL, and VLDLĀ 
  • (09:32)Ā Cholesterol is a "passenger" on a train Ā 
  • (12:09)Ā LDL vs HDL - why one is dangerous and the other isn't
  • (17:42)Ā Raising HDL doesn't reduce heart disease risk the same way as lowering LDLĀ 
  • (19:13)Ā Leaky gut and inflammation increase VLDL production to protect the body
  • (30:38)Ā The misconception that dietary cholesterol significantly raises blood cholesterol
  • (40:56)Ā Saturated fats vs carbohydrates in raising cholesterol and CVD risk
  • (53:08)Ā Statins are a reliable, but imperfect, therapy for lowering CVD risk
  • (01:08:20)Ā Measuring cholesterol particle size refines risk assessment and informs medication use

If you're interested in learning more, you can read the full show notes here.

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Transcript

Click on a timestamp to play from that location

0:00.0

Hello everyone. In this podcast, I'm honored to chat with Dr. Ronald Kraus. Dr. Kraus received his medical degree from Harvard University.

0:08.0

He is a board-certified physician in internal medicine, indecontology and metabolism, and he's one of the top scientists in his field of cardiovascular research.

0:16.0

Ron is really one of the pioneering scientists that changed the way we all think about cholesterol and saturated fat.

0:23.0

He developed an assay that allows the quantification of low-density, light-proprotein particle size and concentration known to the wider world as LDL cholesterol based on a technique which determines the size of the particle based on physics, meaning the speed at which it flies through the air.

0:41.0

Ron and I discuss what HDL and LDL cholesterol are, what they do in the body, and how they play a role in heart disease.

0:49.0

We talk about what small, dense LDL particles are, how they form, what effect eating saturated fat versus refined carbohydrates have on LDL particle size and heart disease risk, and more generally what the main risk factors for heart disease are.

1:05.0

Ron also talks about the good, bad, and the ugly of LDL lowering cholesterol drugs known as statins and much more.

1:13.0

This episode is loaded with so much good information I literally could sit and talk to Ron for hours.

1:19.0

Normally I would take this time to tell you about my crowdfunding campaign, but I will avoid getting into the details on that right now.

1:25.0

If you want to learn more about how to support the podcast or what my crowdfunding is about, you can check it out on my website at foundmyfitness.com or on patreon patrion.com forward slash foundmyfitness.

1:40.0

Today instead I'm going to tell you about a few ways you can stay in touch with what I'm doing outside of these podcasts.

1:46.0

The first way is to go download one of my mobile apps. I have both an Android app and an iPhone app that is a great way to receive occasional updates as well as the hottest news and science health fitness, nutrition, neuroscience, and aging.

2:00.0

To try out one of my apps, search on either Google Play or iPhone App Store for foundmyfitness.

2:07.0

The second way you can stay up to date is by following me on Twitter or Facebook where I try to share one interesting news story every single day and enjoy chatting with many of you almost daily.

2:17.0

Head over to twitter.com forward slash foundmyfitness and facebook.com forward slash foundmyfitness to connect with me there.

2:25.0

I hope you all really enjoy this podcast.

2:29.0

Welcome to another episode of the Foundmyfitness podcast. I'm sitting here with Dr. Ronald Kraus who is the director of the Atharose Grosses Center at Children's Hospital Oakland Research Institute and he's an adjunct professor at University of California San Francisco.

2:44.0

I personally think of Dr. Kraus as one of the scientists that played a very important role in changing the way we think about cholesterol.

2:55.0

The way that he was able to do that was developing an assay that is able to differentiate between the different sizes of lipoproteins that carry cholesterol.

3:08.0

Now let Ron talk a little bit more about that but thanks for being here Ron.

3:13.0

Well I'm delighted to have this conversation.

3:15.0

So for decades we have we meaning you know most most people have this idea in our minds that there are two types of cholesterol.

...

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