#003 5 to 7x More Stem Cells from Placenta with Dr. Frans Kuypers

FoundMyFitness

Rhonda Patrick, Ph.D.

Nutrition, Health & Fitness, Medicine

4.8 • 5.8K Ratings

🗓️ 17 December 2014

⏱️ 62 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this interview, Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab's discovery on how the human placenta is a rich source of pluripotent stem cells, and yet the placenta is thrown away after delivery.

In this episode, we discuss...

(00:00) Introduction
(04:39) The human placenta as a source of hematopoietic cells
(11:30) Pluripotent cells can differentiate into any cell in the human body
(13:03) Public banking of abundant pluripotent placental stem cells
(18:06) Therapeutic applications of stem cells
(22:56) Stem cells as part of a physician's toolkit
(28:56) Epigenetics of induced pluripotent stem cells
(34:49) Biogenerators could use young cells to produce growth factors and other chemicals
(38:36) Transferring blood from young mice into old mice regenerates tissues using GDF11
(43:32) Opportunities and challenges of banking stem cells
(52:49) Stem cells could eliminate deaths due to lack of bone marrow donors
(56:37) The way we fund research isn't optimal for society

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Transcript

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0:00.0	Dr. Ronda Patrick here, and this week's podcast I chat with Dr. Franz Kipers, whose lab
0:05.7	made a huge breakthrough in 2009 because they found that human placenta is a rich source
0:10.5	of pluripotent stem cells.
0:12.3	They also developed a technique that allowed them to retrieve between 5 and 7 times more
0:17.3	hematopoietic stem cells from the placenta than from cord blood, which is currently a
0:21.9	standard technique that's used to get hematopoietic stem cells used for bone marrow transplants.
0:27.0	Meanwhile, the placenta is discarded and thrown away after delivery about 3.9 million times
0:34.1	a year in the US alone.
0:36.1	The ability to retrieve between 5 and 7 times more hematopoietic stem cells from the placenta
0:41.1	than from cord blood is a pretty big deal in the case for bone marrow transplants, which
0:45.0	are typically used to treat a variety of different blood cancers like leukemias and lymphomas,
0:49.9	and also genetic blood disorders like sicklecelinemia.
0:53.1	In the case for blood cancers, often times chemotherapy treatment like radiation and other
0:57.8	chemo drugs can wipe out the immune cells and red blood cells in the body.
1:02.6	Hematopoietic stem cells, which are multi-potent, meaning they have the capacity to form different
1:07.0	cell types in the body, although they're very limited to the types of cell they can form,
1:11.4	can repopulate the immune cells and red blood cells so they can form B and T lymphocytes,
1:16.2	red blood cells as well as other monocytes.
1:19.3	In addition to these hematopoietic stem cells, the placenta also has the capacity to form
1:23.7	pluripotent stem cells, which means these stem cells can form any type of cell in the body,
1:29.6	including blood cells, immune cells, muscle cells, lung cells, liver cells, kidney cells, brain
1:35.6	cells, you get the point.
	...

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