Ziprasidone Pharmacology
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
4.9 • 773 Ratings
🗓️ 7 January 2021
⏱️ 13 minutes
🧾️ Download transcript
Summary
On this episode of the Real Life Pharmacology Podcast, I cover ziprasidone pharmacology.
Ziprasidone has dopamine blocking activity and is classified as a second generation antipsychotic.
Ziprasidone tends to have lower metabolic syndrome risks compared to other antipsychotics like clozapine and olanzapine.
QTc prolongation is a significant risk with ziprasidone and be aware of drug interactions and electrolyte imbalances that may increase this risk.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
Transcript
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| 0:00.0 | Hey, all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacist Eric Christensen, |
| 0:06.0 | and I thank you so much for listening today. If you enjoy the podcast today, definitely go pick up your |
| 0:12.4 | free resource. It's the top 200 drugs. It's a study guide I put together on highly testable |
| 0:20.0 | clinical pearls, as well as things you're going to see in |
| 0:23.0 | real life as well with the top 200 drugs there. |
| 0:26.8 | Over a 30 page PDF, absolutely no cost to you. |
| 0:32.6 | Just you'll get on our email list. |
| 0:34.3 | We've got new podcast episodes and things coming out. You'll get updates with that. |
| 0:39.3 | So again, real-life pharmacology.com. Check out that free PDF for subscribing. |
| 0:47.5 | All right. So let's get into the drug today. We're going to cover Ziprazadone, which the brand name of |
| 0:53.9 | that medication is Giodon. |
| 0:56.9 | And this is classified as an antipsychotic. |
| 1:01.5 | Specifically, it is a second generation antipsychotic. |
| 1:07.6 | With virtually any antipsychotic, the primary uses you're going to see are schizophrenia, |
| 1:15.6 | you know, delusional behavior, hallucinations, bipolar disorder with mania, things like that. |
| 1:24.6 | Occasionally, in my practice, I have seen it used off-label for dementia-related psychosis. |
| 1:33.5 | Of course, we certainly need to remember that there is a boxed warning for increased risk of death |
| 1:40.2 | with the use of antipsychotics for that diagnosis, however. |
| 1:45.0 | So important to keep that in mind. |
| 1:49.4 | Mechanistically, I have covered some antipsychotics in the past. |
| 1:55.6 | Primarily, we're looking at the blockade of dopamine receptors. |
| 2:05.7 | It may have some antihistamine type effects, |
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