meta_pixel
Tapesearch Logo
Log in
Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Ziprasidone Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 7 January 2021

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this episode of the Real Life Pharmacology Podcast, I cover ziprasidone pharmacology.



Ziprasidone has dopamine blocking activity and is classified as a second generation antipsychotic.



Ziprasidone tends to have lower metabolic syndrome risks compared to other antipsychotics like clozapine and olanzapine.



QTc prolongation is a significant risk with ziprasidone and be aware of drug interactions and electrolyte imbalances that may increase this risk.

Transcript

Click on a timestamp to play from that location

0:00.0

Hey, all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacist Eric Christensen,

0:06.0

and I thank you so much for listening today. If you enjoy the podcast today, definitely go pick up your

0:12.4

free resource. It's the top 200 drugs. It's a study guide I put together on highly testable

0:20.0

clinical pearls, as well as things you're going to see in

0:23.0

real life as well with the top 200 drugs there.

0:26.8

Over a 30 page PDF, absolutely no cost to you.

0:32.6

Just you'll get on our email list.

0:34.3

We've got new podcast episodes and things coming out. You'll get updates with that.

0:39.3

So again, real-life pharmacology.com. Check out that free PDF for subscribing.

0:47.5

All right. So let's get into the drug today. We're going to cover Ziprazadone, which the brand name of

0:53.9

that medication is Giodon.

0:56.9

And this is classified as an antipsychotic.

1:01.5

Specifically, it is a second generation antipsychotic.

1:07.6

With virtually any antipsychotic, the primary uses you're going to see are schizophrenia,

1:15.6

you know, delusional behavior, hallucinations, bipolar disorder with mania, things like that.

1:24.6

Occasionally, in my practice, I have seen it used off-label for dementia-related psychosis.

1:33.5

Of course, we certainly need to remember that there is a boxed warning for increased risk of death

1:40.2

with the use of antipsychotics for that diagnosis, however.

1:45.0

So important to keep that in mind.

1:49.4

Mechanistically, I have covered some antipsychotics in the past.

1:55.6

Primarily, we're looking at the blockade of dopamine receptors.

2:05.7

It may have some antihistamine type effects,

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2025.