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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Tiotropium Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 31 December 2020

⏱️ 14 minutes

🧾️ Download transcript

Summary

On this episode, I discuss tiotropium pharmacology. In addition, I cover adverse effects, administration pearls, and drug interactions.



Tiotropium blocks acetylcholine from binding the M3 receptor in the lungs. This leads to a relaxation of the bronchial smooth muscle.



Because tiotropium has anticholinergic activity, there is a potential for anticholinergic adverse effects like constipation, urinary retention, and dry mouth.



The tiotropium Handihaler can be confusing to patients. I discuss medication misadventures in this podcast episode.

Transcript

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0:00.0

Hey, all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen,

0:06.9

and I thank you so much for listening today. Hopefully you pick up a few clinical pearls along the way.

0:14.2

And of course, speaking of clinical pearls, go check out real-life pharmacology.com. And subscribe there, and I'll give you a 30 plus page PDF on the top 200

0:28.0

drugs, kind of a unique little study guide that I personally put together where I lay out

0:35.2

important clinical pearls that you're going to see in clinical practice,

0:40.2

as well as things that commonly come up on board exams and things of that nature as well.

0:46.6

So if you've got anything to do with pharmacology, well, you're likely here for a reason.

0:52.6

So let's get into it with the drug of the day today.

0:56.1

And that is going to be teotropium.

0:59.2

And the brand name of this medication is Spireva.

1:03.6

Its primary use is in respiratory disorders.

1:08.8

More specifically, COPD. It's considered a long-acting anticholinergic

1:17.4

medication, also referred to as a long-acting muscarinic antagonist. Sometimes you'll hear the term

1:27.1

llama used as an acronym to kind of describe its classification.

1:32.3

And this drug works by essentially blocking acetycholine's action at muscarinic receptors, specifically M3 receptors or muscarinic three receptors.

1:49.2

And when acetylcholine binds those M3 receptors, what it leads to is bronchon constriction.

1:59.2

So basically that airway closing up.

2:03.0

And so if we prevent the cetocoline from binding those M3 receptors,

2:10.7

we can help cause the opposite,

2:12.7

which is broncholilation or that relaxation of the airway there, which obviously allows for better breathing.

2:23.7

Okay, so I said primary use is COPD. It can be used for asthma. It's typically a further down the

2:31.8

line type of medication in patients that aren't controlled

...

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