meta_pixel
Tapesearch Logo
Log in
Short Wave

Your DNA is changing all the time. Here’s why

Short Wave

NPR

Nature, Daily News, Science, Life Sciences, News, Astronomy

4.76.6K Ratings

🗓️ 9 June 2026

⏱️ 14 minutes

🧾️ Download transcript

Summary

We tend to think of the DNA strands that contain our genetic code as consistent, stable units. But in reality, the cells that make up our bodies are constantly replicating and changing. Even as you read this sentence, in fact, the genes within your cells are mutating. So, what causes these mutations and what’s the impact? Science writer Roxanne Khamsi examines the answers in her new book, Beyond Inheritance. Today on the show, she gets into how scientists examine these mutations, how they’ve shifted our understanding of disease and what the future of genetic therapy could entail.

Interested in more biological and life sciences? Email us your question at shortwave@npr.org.

Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

See pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.

NPR Privacy Policy

Transcript

Click on a timestamp to play from that location

0:00.0

You're listening to Shortwave from NPR.

0:05.1

Shortwavers, I'm going to take us back to high school biology, the genetics chapter.

0:11.1

You may have learned that the human body is made up of trillions of cells, and inside those cells are DNA molecules, those strands that contain the genetic code that makes you, you. But here's something

0:22.3

that may surprise you and you may not have learned in school. That DNA is not the same for every

0:28.7

cell. And that's because DNA is constantly changing. There's actually trillions of mutations

0:34.2

happening in your cells every day. This is Roxanne Comsi. She's a science journalist and a contributing writer at The Atlantic.

0:40.5

We're just constantly in flux, partly because there's just wear and tear, like genes will get

0:46.0

turned on and sometimes things will break, and then enzymes will come in and try to fix it,

0:50.5

but they won't always do the best job fixing it. So we are kind of a landscape of

0:56.2

genetic diversity, each of us, just by nature of all the DNA changes, all those errors that

1:01.7

pile up over the course of our lives. By the way, scientists have known for decades that our genes

1:06.2

mutate. It's just that in the last decade, DNA sequencing has gotten so much more powerful and precise.

1:12.5

The scientists can now read the genetic code of individual cells.

1:17.1

There's been this possibility to kind of do a census of the cells in a body

1:21.3

and figure out which ones have which mutations that the other cells don't have.

1:25.9

So then here we are, grasping this diversity,

1:29.1

this genetic diversity that exists inside us. And it turns out there is a lot of genetic diversity

1:34.6

going on inside us, so much so that Roxanne wrote an entire book about it called Beyond Inheritance

1:41.2

are ever mutating cells and a new understanding of health.

1:45.0

People hear the word mutation, and they immediately think about something negative,

1:49.8

but there's also good things that can happen with mutation.

1:54.3

So today on the show, genetic mutations, like you've never seen them before.

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from NPR, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of NPR and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.