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Work in Progress with Sophia Bush

Work in Progress: Caterina Scorsone

Work in Progress with Sophia Bush

iHeartPodcasts

Music, Arts, Comedy

4.73.3K Ratings

🗓️ 10 December 2025

⏱️ 54 minutes

🧾️ Download transcript

Summary

"Grey's Anatomy" star Caterina Scorsone reflects on what led a curious kid from Toronto to embody Dr. Amelia Shepherd, one of the most complex, electric characters on television today. 

Caterina addresses Amelia’s uncertain future on the series while standing fiercely clear-eyed in her real-life role, advocating for her daughter with Down syndrome and anyone denied accommodation for their uniqueness.

Learn more about Caterina's passions - Global Down Syndrome Foundation and Modo Yoga LA.

See omnystudio.com/listener for privacy information.

Transcript

Click on a timestamp to play from that location

0:00.0

This is an I-Heart podcast.

0:02.3

Guaranteed Human.

0:04.4

Hi, everyone. It's Sophia.

0:06.8

Welcome to Work in Progress.

0:19.0

Welcome back to Work in Progress. Friends, fans, listeners, and internet pals.

0:26.3

This is an episode you all have been waiting for and telling me you've been waiting for.

0:31.8

We are finally joined on Work in Progress this week by none other than Katarina Scorsone.

0:40.4

She is one of those rare performers who brings a stunningly present emotional intelligence to every role.

0:48.9

She's best known for her more than a decade-spanning turn is Dr. Amelia Shepard on Grey's Anatomy.

0:55.2

She has built a gorgeous career playing complicated, honest, fiercely human women, characters

1:01.1

who fall apart and rebuild and somehow emerge even more whole than before.

1:07.3

But her story off-screen is just as compelling.

1:10.4

Katerina was born and raised in Toronto in a very creative household, one of five siblings.

1:15.2

She's been acting professionally as a child, but took a little left turn thinking she might

1:20.4

actually be a doctor, only to boomerang all the way back and become one on TV.

1:25.4

Her parents were academics who also ran homeless shelters. So from a

1:29.5

really early age, she's had a keen sense of life's complexities and how important it is for us to

1:36.2

show up in service of each other. She has managed to merge all of her passions in such a meaningful

1:41.7

way on and off screen. And perhaps off screen, she's taken on her most meaningful role of all, as a mother of three,

1:49.4

and now an incredible advocate for disability inclusion, drawing from her experience, raising

1:55.3

one of her three daughters with Down syndrome.

1:58.3

She chooses to use her platform to promote greater understanding, to end

...

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